ID H2ZYF8_LATCH Unreviewed; 619 AA.
AC H2ZYF8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002429.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002429.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01260276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZYF8; -.
DR STRING; 7897.ENSLACP00000002429; -.
DR Ensembl; ENSLACT00000002449.1; ENSLACP00000002429.1; ENSLACG00000002169.1.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT01100000263560; -.
DR HOGENOM; CLU_000384_9_11_1; -.
DR InParanoid; H2ZYF8; -.
DR OMA; SKWLAHY; -.
DR TreeFam; TF352304; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR PANTHER; PTHR37984:SF13; RIBONUCLEASE H; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 35..49
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 252..430
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 619 AA; 69639 MW; 9F20CC6E289646FC CRC64;
RKPKPQASST KPKQLCYCCG GNHQQSTCRF RHESCHGCGK IGHLMRVCKT TSRTAQTQYI
TDTVLEAEQE KESLELFTVY TTQIGLGDKP VSMQLDTGAS VLLVPEHIYK SCLSKCPLQP
SLIQLTSYIG DQIPVLGEIQ TPVTYEGRAW TLPLVVVQGN RPALLGRNWL DKIKLNWDKI
FTLCAKTVAS QDAVSKVLDK HDPLFQEGYG TITDFKAKIQ VKKGATPIFH KPRPISYALK
EPVEKELYCL ERHSIISPIK RSNWAAPIVV VPKKDKSVRL CGEDKVTVNS CVEPEPYPLP
NAKDLFATLA GRKFFIKLDL SFAHQQLELE PGSEPFLTIN IQKGLYRYHQ LTYGVSTVPA
IFQNTMDQIL HSLDRAVCCM DDILVTAPTI EEHLATLDQV MSRLQQYGVR VKRAKCQFLQ
DSVGYLGYQT DPGAAPTEGK VAAIVNAPAP KNVMELQSFL GLLNYYGRFL ANLSTLLQPL
HDLLQKDAKW NWSPQCEATF QTCKQLLLNS KWLAHYDPTK PLRLACDVSP YGVDHVLPSG
EEHPIAFASR ILSPSERNYA QIEREALSII FGVKKFYKYF YGCKFTFLTD HKPLLVILRP
KAAIQTLAAL RMQRWALTL
//
