ID H2ZYY9_LATCH Unreviewed; 869 AA.
AC H2ZYY9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102352815 {ECO:0000313|Ensembl:ENSLACP00000002610.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002610.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01226599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZYY9; -.
DR Ensembl; ENSLACT00000002631.1; ENSLACP00000002610.1; ENSLACG00000002336.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H2ZYY9; -.
DR OMA; CCFSCVS; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..869
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003578828"
FT TRANSMEM 601..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 601..865
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 869 AA; 96570 MW; E31FA33196789F45 CRC64;
AEMLPVFLLF LMLSASVYES TQPGCKLPGS KVKGTFQDGD IIIGGIFPLY SKTDFSETLW
KEPPKPISCE IFGFRPYRWI QAMVFTIKEI NQNSELLPNI TLGYMIYDSC GLATWALEGT
MRLITGQEEP IPNYQCHLQS PLAAIIGDGG STASIPMARL LGLYDYPQIS YFASVPLLSD
KSQFPSFFRT IPSDNFQSHG LAQLVTHFGW TWVGILVEDT EYGELSGQSL KEEVLKAGAC
IAFFETTPIE YSERRFHEVI TKIKQSLANA IVVMSYDSYL IAFMEEVARQ NVTGKVWIAS
EAWSTSQILS KKELLKTLSG TIGFAIRRGK IPGFKGFLTS LQTSRFKNDI FMKTFWEQAF
GCKWASQDSY RTTSNTEIGT AFTVCTGTEN LGALNISFFD VSDLRITYNV YNAVYSVAHA
LHDLNSCVPG EGPFGNGACA HIQTFEAWQL LHYVKNVNFN NNNGEKVFFD PNGNPPAHYD
ILNWQLHPDG TIDFVQVGTF DASAPVGHQL IINESAIMWN GERVQVPRSV CSESCSAGYR
KAARRGQPIC CFDCIPCSSG EISNQSDSTE CTKCPDDQWS NDRQDKCIPK STEFLSYDEP
MGVTLASISI FSALIPVTIL YIFIKNRNTP LVKANNRELS YLLLLALMLC FLCSLNFIGN
PSRVACMLRQ VAFGIVFALC VSCVLAKTIM VVIAFNATKP NSNLKKWVGP KLPNAIVFVC
TVIQVIICIV WLSISPPFPE HNMKSQIGVI IKECNEGSTT AFWCMLGYMG LLAIVSFVVA
FLAKNLPDSF NEAKFITFSM IVFVTVWLSF IPAFLSTRGK YMVAVEIFAI LASTAGLLAC
IFLPKCYIIL LRPHINTREY LMGKGSKST
//
