ID H3A157_LATCH Unreviewed; 527 AA.
AC H3A157;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Solute carrier family 29 member 4 {ECO:0000313|Ensembl:ENSLACP00000003378.1};
GN Name=SLC29A4 {ECO:0000313|Ensembl:ENSLACP00000003378.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003378.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; AFYH01215203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01215204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01215205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01215206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006010241.1; XM_006010179.1.
DR AlphaFoldDB; H3A157; -.
DR STRING; 7897.ENSLACP00000003378; -.
DR Ensembl; ENSLACT00000003408.1; ENSLACP00000003378.1; ENSLACG00000003018.1.
DR GeneID; 102357831; -.
DR KEGG; lcm:102357831; -.
DR CTD; 559668; -.
DR eggNOG; KOG1479; Eukaryota.
DR GeneTree; ENSGT00950000182898; -.
DR HOGENOM; CLU_021611_4_0_1; -.
DR InParanoid; H3A157; -.
DR OMA; ARGMNEF; -.
DR OrthoDB; 2939652at2759; -.
DR TreeFam; TF313950; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF89; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 2.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 58384 MW; EC5DBD36FCFBA528 CRC64;
MGSVRGGGSL SRGNPAPNSE GNVVVSFSFD TYQLEEEENQ GRETQSKGVL TFTEPVPDEA
VPQDCYRGIY FAMLLAGVGF LLPYNSFITD VDYLHHKYPG TSIVFDMSLT YILVALIAVI
LNNALVELLS LHTRITVGYL FALGPLVFVS VCDVWLGLFA VKQAYAINLV AVGVVAFGCT
VQQSSFYGYT GMLPKRYTQG VMTGESTAGV IISLSRIFTK LLLSDEKKNT IIFFFISISI
ELLCFVLQLL VRRTRFVQYY TACAKQSEVE LKGHDSDGMG YRVHHDVVAE EVRFENRTAG
DSIPESLHSE VEFTGSSTYM RFDVGKPRIK KSWPGLRDMV LHRYVVARVI WPYMLSIAVT
YFITLCLFPG LESEIRNCML GEWLPILIMA IFNLSDFVGK ILAALPYSWN GTRLLICSCL
RVIFIPLFIM CVYPSGQPAF SHPAWPCIFS LLMGITNGYF GSVPMILAAG KVSTEQRELA
GNTMTVSYMS GLTLGSAVAY VAYHLTSTSH STCFHTETTN SSFTAAY
//
