ID H3A2C6_LATCH Unreviewed; 501 AA.
AC H3A2C6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU362067};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU362067};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003797.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362067};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|RuleBase:RU362067}.
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DR EMBL; AFYH01183174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01183175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01183176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A2C6; -.
DR STRING; 7897.ENSLACP00000003797; -.
DR Ensembl; ENSLACT00000003831.1; ENSLACP00000003797.1; ENSLACG00000003383.1.
DR eggNOG; KOG0029; Eukaryota.
DR GeneTree; ENSGT00940000160928; -.
DR HOGENOM; CLU_004498_8_3_1; -.
DR InParanoid; H3A2C6; -.
DR OMA; YSTRQFL; -.
DR TreeFam; TF313314; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008131; F:primary amine oxidase activity; IEA:UniProt.
DR Gene3D; 1.10.10.1620; -; 1.
DR Gene3D; 3.30.70.2100; -; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR PANTHER; PTHR10742:SF342; AMINO_OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 2.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU362067};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU362067}; Membrane {ECO:0000256|RuleBase:RU362067};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362067};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU362067};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362067}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..501
FT /note="Amine oxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579815"
FT TRANSMEM 127..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362067"
FT DOMAIN 68..121
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
FT DOMAIN 253..500
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 501 AA; 57032 MW; D05A28AA7233BC20 CRC64;
PAMTSLLVSF PVFLLAWFLL GMQAAKTEQD PLSECFKDPD YEELLNIAKR GLPKHSSPKH
IIIVGAGIAG LVAATVLEQA GHNVTILEAS DRVGGRIHTY RPHTGDWYAE LGAMRLPTSH
QMLHRKGLGF FFLLFRTFFL FLMLRFHSYK WAFQAGPPEM LQYQDRGLKH SSKHFLILKI
IFFQVREDLK NSNCSYVLKK YDAYSVKQYL VDVCKLSKGA VQMVGDILND QSLFHTAFSE
RLRLQAANNN KVHFKQIVGG TDRLPRAFQD RIKSPIYLNS QVIAINQTGD KVTVFYKETA
YNFFSELQAD YVLITITARA TKFLDFHPAL SLSKIRALHA VHYGCSTKIL LVFREKFWEK
DKIHGGKSIT DLPSRLIFYP SHTFQSNVGV LLASYTWSDE SSSFLGLSDE ECIMAALNDV
AKIHGEHIRE LLESGVVKKW STDPYSLEAF ALYTPYQLRE YTEDLFKKEG RIHFAGEHTT
LSHAWIETAM KSALKAARNI N
//
