ID H3A3G7_LATCH Unreviewed; 521 AA.
AC H3A3G7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Neuropilin and tolloid like 2 {ECO:0000313|Ensembl:ENSLACP00000004188.1};
GN Name=NETO2 {ECO:0000313|Ensembl:ENSLACP00000004188.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004188.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; AFYH01235004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01235005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01235006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01235007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01235008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A3G7; -.
DR STRING; 7897.ENSLACP00000004188; -.
DR Ensembl; ENSLACT00000004225.1; ENSLACP00000004188.1; ENSLACG00000003724.1.
DR eggNOG; ENOG502QW0Z; Eukaryota.
DR GeneTree; ENSGT00940000156041; -.
DR HOGENOM; CLU_015228_0_1_1; -.
DR InParanoid; H3A3G7; -.
DR OMA; SFKQSHD; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF26; NEUROPILIN AND TOLLOID-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..521
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003578945"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..162
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 180..288
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 48..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 293..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 300..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 312..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 521 AA; 59141 MW; C6D5DAC8E1FEC21D CRC64;
NLSLSLFCSY SFTVMLIIII LVEEGLAVAQ KTQEGQNPGT KHFSAAQCGI WVRTINGGHF
SSPNFPTSYP PNKECVYILE ASPRQRIELT FDEPYYIEPS FECRFDHIEV RDGPFGFSPL
INRYCGLKSP TLIRSTGRFM WIKFSSDEEL EGLGFRAKYS FIPVPSFSYG PLYIHTDRQA
NGGSRTTSGK KKEKKSPATK LDCSVLLNTV KNLRIYLRFL DYQMEHSNEC KRNFVAVYDG
SSAIENLKAK FCSTVANDVM LETGIGVIRM WADEGSRLSR FRMLFTSFVD PPCSGSTFFC
HSNMCINSSL VCNGVQNCAY PWDENHCKEK KEPGLLEQIT KTHGTVIGVS SGIVLVLLII
SILVQVKQPR KKVMARKAAF NKSGFQEVFD PPHYELFSLR DKEISADLAD LSEELENYHK
IRRSSTASRC IHDHHCGSQT SSTKQSRTNL SSLDLPFRND FSQPQPMKTF NSNFKKSCYS
FKQSHDCPEQ VIEDRVMEEV PCEIYIRGRE DSVQRSMSID F
//
