ID H3A402_LATCH Unreviewed; 863 AA.
AC H3A402;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102358292 {ECO:0000313|Ensembl:ENSLACP00000004373.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004373.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004373.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01233560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A402; -.
DR Ensembl; ENSLACT00000004411.1; ENSLACP00000004373.1; ENSLACG00000003887.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01100000263565; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H3A402; -.
DR OMA; PFGIPMI; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF504; EXTRACELLULAR CALCIUM-SENSING RECEPTOR ISOFORM X2-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..863
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579944"
FT TRANSMEM 599..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 599..863
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 863 AA; 96651 MW; 28F37BC5CB3E859D CRC64;
VWEDFKMYSH LRSILLIIIA QSAQGSGEPV CRSLGNFELS GLLQEGDIII GGLFPMHYRV
VVPDLGYMHK PRASGCYGFD FRSFRWAQVM RYAIKEINED PSFLSNITLG YKIYDSCATH
VAALRATFTI LGNPEDTLSN ITCTGTHSVL AFIGDSGSSQ SIVVAKVLGP FSIPMISYFS
TCACLGDKQE FPTFFRTIPS DMFQIKAIAQ LVKHFGWTWI AAVSEDDDYG RYGIQALTEE
VEKNGICVAY YEIIPKVYNR QRILEIVKKI KNSSAKIVVA FSGEGELYPL LEEVVHQNIT
GIQWIASEAW ITAALFSPPK YYRFLGGTIG FAVRRGDIPG LKNFLLTVHP SSFPNNSLVK
EFWETMFDCT LGTSHSIEQS IKCTGEKTLE GKNNLYTDIT QLRISYNVYK GVYAIAHSLK
NLINCKQNKG PFINKTCADI TQLEPWQLQH YVQEVSFVNS MREEVNFDEN GDPIASYDII
NWQRSKDGSI QFVPVGRFDE AEGVGHELLI DEDAIIWNGE QTKVPESVCS ESCAPGTRKG
IREGEPVCCF DCLPCADGEI SNQTDSVECI KCPEDYWSNQ QRFQCIPKEI EYLSFKEPMG
IVLTLVALFG VCLTTTVILV FFYYRSTPIV RANNSELSFL ILLSLILCFL CSIIFIGQPT
TWNCILRYTV FGISFSLCIS CILCKTVVVL MAFKVTVPGS SIIKLFGPVQ QRAVISACGL
IQVIICIVWL TMAPPYAFKN TQYQSGKIIL ECGVESALAF WSVLGYIGLL ACICFLLAFF
VRKLPDNFNE AKYITFSMLI FSAVWIAFIP AYVSSPGKYT VAVQIFAILS SSFSLLTCIF
FPKCYIILLK SENNSKQFLM GRK
//
