ID H3A6X1_LATCH Unreviewed; 479 AA.
AC H3A6X1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Zinc finger SWIM-type containing 2 {ECO:0000313|Ensembl:ENSLACP00000005392.1};
GN Name=ZSWIM2 {ECO:0000313|Ensembl:ENSLACP00000005392.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005392.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01201003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A6X1; -.
DR Ensembl; ENSLACT00000005440.1; ENSLACP00000005392.1; ENSLACG00000004797.2.
DR GeneTree; ENSGT00390000006826; -.
DR HOGENOM; CLU_029121_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16486; mRING-H2-C3H2C2D_ZSWM2; 1.
DR CDD; cd16494; RING-CH-C4HC3_ZSWM2; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR007527; Znf_SWIM.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR InterPro; IPR039903; Zswim2.
DR PANTHER; PTHR21540:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2; 1.
DR PANTHER; PTHR21540; RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF04434; SWIM; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50089; ZF_RING_2; 2.
DR PROSITE; PS50966; ZF_SWIM; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 49..82
FT /note="SWIM-type"
FT /evidence="ECO:0000259|PROSITE:PS50966"
FT DOMAIN 145..197
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 228..279
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 345..386
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 111..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 55348 MW; CC24BCC390F4318A CRC64;
MFRSSVWRRT INDLVHWHQE QASSTTIYIL REFGPTGFLL KEEGETKTFK VLLGDPHSCN
CSTFLKERDL CKHICWVLLK KFRLPRDHEY TFQLGLVERE INELLQGLHQ MQTPRPPVNS
PSSKQTPADR DGYIRQKDID AEDICPICQE ELLQKMLPVT YCKYGCGNSV HITCMKVWAD
HQLQSKDDIM VRCPLCREEF APLKLLLEEL KNSNSLITAA EKERLDKHLG IICNNCRVFP
IKGMCYKCSE CTDYHLCQQC FVSCCHSQHI FVFRQKRNQR WMPVEQKTGQ PLTTAINVTD
LENKALFPHN SPQQELICTP IHVFKTLSST MVRQGSKLLA PGQQCRICLK AFSLGQFVRQ
LPCRHKFHKE CIDYLLLNER NSCPLDGQVI YNLLRWKEPL SKEKTKPSIF QDNIIKVQQQ
IEPQLFIPGI GLTVKKKCTR TQNEQPISLQ GQNSQISTVT QQDLTLTGLR CLQLNKANS
//
