ID H3A9T0_LATCH Unreviewed; 601 AA.
AC H3A9T0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Translocase of outer mitochondrial membrane 70 {ECO:0000313|Ensembl:ENSLACP00000006401.1};
GN Name=TOMM70 {ECO:0000313|Ensembl:ENSLACP00000006401.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006401.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004572}.
CC -!- SIMILARITY: Belongs to the Tom70 family.
CC {ECO:0000256|ARBA:ARBA00038030}.
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DR EMBL; AFYH01199394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01199395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01199396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01199397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01199398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A9T0; -.
DR STRING; 7897.ENSLACP00000006401; -.
DR Ensembl; ENSLACT00000006454.1; ENSLACP00000006401.1; ENSLACG00000005679.1.
DR eggNOG; KOG0547; Eukaryota.
DR GeneTree; ENSGT00940000157095; -.
DR HOGENOM; CLU_017516_2_0_1; -.
DR InParanoid; H3A9T0; -.
DR OMA; QWRGDIE; -.
DR TreeFam; TF106203; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000005679; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46208; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR PANTHER; PTHR46208:SF1; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 103..136
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 394..427
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 469..502
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 538..571
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 63..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 67169 MW; C64DD916F9119CA5 CRC64;
PAEPPPPRRL STDRLLVAGS VMAASKPVEP QAGTGLPRWQ LALMVGAPLL VGAGVVYLWS
RRRKNKRSGE RKTPEGRASP VPGKQDPARG QSQEETMGPL DRAQAAKNKG NKYFKAAKYE
QAIQCYTEAI SLCPPEQKGD LSTFYQNRAA AYEQLDTETG VTRVLWSQFQ LNNGMQKKME
LLLNNLSAHT SVSVKLILVS LDVTAVCILE SFQNQQSMVV ADRVLKLLGK EKAKEKYKNR
EPLMPSPQFI KSYFSSFTDD IISQPLLKGE KADEDKDKEG EAAEVKESSG YLKAKQYMEE
ENYDKIISEC TKEIDGKGKY LAEALLLRAT FYLLIGNAAA AKPDLDKVIA MEEANVKLRA
NALIKRGSMY MQQQQPLLST QDFNLAADID PQNADVYHHR GQLKILLDQV EDAVEDFDEC
IRLRPDSALA QAQKCFALYR QAYTGSNPSQ VQMAMKGFED VIQIFPKCAE GYALYAQALT
DQQLFGKADE MYDKCIELEP DNATTYVHKG LLQLQWKQDL DKGLELISKA IEIDNKCDFA
YETMGTIEVQ RGNLDKAIEM FNKAINLAKS EMEMAHLYSL CDAAYAQTEV AKKYGLKPPT
L
//
