ID H3ACZ7_LATCH Unreviewed; 740 AA.
AC H3ACZ7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PAK5 {ECO:0000313|Ensembl:ENSLACP00000007518.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007518.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007518.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01178908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ACZ7; -.
DR STRING; 7897.ENSLACP00000007518; -.
DR Ensembl; ENSLACT00000007581.1; ENSLACP00000007518.1; ENSLACG00000006666.1.
DR eggNOG; KOG0578; Eukaryota.
DR GeneTree; ENSGT00940000158656; -.
DR HOGENOM; CLU_000288_26_6_1; -.
DR InParanoid; H3ACZ7; -.
DR OMA; KSHPQGH; -.
DR TreeFam; TF105352; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006666; Expressed in muscle tissue and 3 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06658; STKc_PAK5; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR028754; STKc_PAK5.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF27; SERINE_THREONINE-PROTEIN KINASE PAK 5; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 23..36
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 470..721
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 108..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 500
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 740 AA; 84314 MW; D0A744B122EB059C CRC64;
MHHFPGISGF STMFGKKKKK LEISAPSNFE HRVHTGFDHR EQKFTGLPQQ WQSLLADTAN
RPKPVVDPSC ITPIQLAPMK TIVRGNKPPK DTSINGLLEE FDSISVTRSN SLRKESPPAP
RQANSNHIQD RPEENGYGRY YSRYSCEFDT AKGYVSEKYN EWKYYEDDMD RHYKSSRTSK
QNGHATRTKP GDACYPDAKA QKADFSRLLP DHHAYPEQRH RSADHCVTKW DYQMSLTGFP
SEYREPSQTA LCRSVIHSEF SKERVEYNEN DWSYGTTRED YEKRPKSSYV NQTSPEPAMR
QRSRSGSGLQ EPSTPQGASA FKSAQQGHSY SSYTYPRLSE TITTAYIPKG DYDRVQRGVS
PQLIGSDTYP RGQPKLPQNQ NNPNYPTSGY QYSTAYNKAS HYNQPPLQPS SQYIVSPAYP
QPSSPCIAQG AYPPPSWGSS SDQQSSRVSH EQFRAALQLV VSPGDPREYL DNYIKIGEGS
TGIVCIATEK HTGKQVAVKK MDLRKQQRRE LLFNEVVIMR DYHHENVVDM YNSYLVGDEL
WVVMEFLEGG ALTDIVTHTR MNEEQIATVC SSVLRALSYL HHQGVIHRDI KSDSILLTSD
GRIKLSDFGF CAQVSKEVPK RKSLVGTPYW MAPEVISRLP YGTEVDIWSL GIMVIEMVDG
EPPYFNEPPL QAMRRIRDNL PPRVKDIHKV SSMLRGFLDQ MLVREPSQRA TAQELLRHPF
LKLTGPASCI VPLMRQYRHR
//
