ID H3AG02_LATCH Unreviewed; 878 AA.
AC H3AG02;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 4 {ECO:0000256|ARBA:ARBA00014934};
DE AltName: Full=26S proteasome regulatory subunit RPN10 {ECO:0000256|ARBA:ARBA00044341};
GN Name=PIP5K1A {ECO:0000313|Ensembl:ENSLACP00000008573.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008573.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008573.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the proteasome subunit S5A family.
CC {ECO:0000256|ARBA:ARBA00005574}.
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DR EMBL; AFYH01140214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AG02; -.
DR STRING; 7897.ENSLACP00000008573; -.
DR Ensembl; ENSLACT00000008641.1; ENSLACP00000008573.1; ENSLACG00000007582.2.
DR eggNOG; KOG0229; Eukaryota.
DR eggNOG; KOG2884; Eukaryota.
DR GeneTree; ENSGT00940000154703; -.
DR HOGENOM; CLU_012562_0_0_1; -.
DR InParanoid; H3AG02; -.
DR TreeFam; TF319618; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007582; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0052742; F:phosphatidylinositol kinase activity; IEA:InterPro.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd17306; PIPKc_PIP5K1A_like; 1.
DR CDD; cd22297; PSMD4_RAZUL; 1.
DR CDD; cd01452; VWA_26S_proteasome_subunit; 1.
DR Gene3D; 6.10.250.380; -; 1.
DR Gene3D; 6.10.300.40; -; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR023610; PInositol-4/5-P-5/4-kinase.
DR InterPro; IPR049590; PSMD4_RAZUL-like.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23086:SF54; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA; 1.
DR PANTHER; PTHR23086; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1.
DR Pfam; PF01504; PIP5K; 1.
DR Pfam; PF02809; UIM; 2.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00330; PIPKc; 1.
DR SMART; SM00726; UIM; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50330; UIM; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Kinase {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00781}.
FT DOMAIN 33..407
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT DOMAIN 506..689
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 413..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 96705 MW; DC7AE9765D356906 CRC64;
MPTSSGLHST LTIKKIGHRG VDSTGETTYK KTTSSALKGA IQLGITHTVG SLSNKPERDV
LMQDFYVVES IFFPREGSNL TPAHHYSDFR FKTYAPMAFR HFRELFEIRP DDYLYSLCKE
PLIELSNSGA SGSLFYVSGD DEFIIKTVQH KEAEFLQKLL PGYYMNVKQN PRTLLPKFYG
LYCVQAGGKN IRIVVMNNLL PRSVKMHLKY DLKGSTYKRR ASMKEREKPL PTYKDLDFMQ
DIAEGLYLDS DMYSALCKTM QRDCLVLQSF KIMDYSLLVG IHNIDQSLRE RELEGHQGTM
DGVMSLDTRK PVGQKALYST PMESIQGGAL NGGTIETEDQ MGGIPARNSK GERLLLYIGI
IDILQSYRFV KKLEHSWKAL VHDGDTVSVH RPGFYAERFQ KFMCTTVFKK IPLRPSPSKK
SRSGLASTRR PPPGGGGATS AQLPLAGEAK GQLSVQVTEA EVEQGTHLGR PDLLPRTPPP
EEATRLSSLS LPLLLNSPQL PEFPNLLYSS VDNSEYMRNG DFLPTRLQAQ QDAVNIVCHS
KTRSNPENNV GLITMANNCE VLTTLTPDTG RILSKLHTVQ PKGKISFCTG IRVAHLALKH
RQGKNHKMRI IAFVGSPVED NEKDLVKLAK RLKKEKVNVD IVNFGEEESN TEKLTSFINT
LNGKDGTGSH LVTVPPGPSL ADALISSPIL AGEGGAMLGL GASDFEFGVD PSADPELALA
LRVSMEEQRQ RQEEEARRAA AASAAEAGIT SPGADDSDDA LLKMTMTQQE TGRSGIPDFS
SMSEDEQIAY AMQMSLQGAA EFGPGGCADE IGAAMDTSEP AKEEDDYDVM QDPEFLQSVL
ENLPGVDPNN EAIRNAMGSL ASQTSKDSKK DKKEEEKK
//
