ID H3AIC4_LATCH Unreviewed; 2366 AA.
AC H3AIC4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=APC regulator of WNT signaling pathway 2 {ECO:0000313|Ensembl:ENSLACP00000009395.1};
GN Name=APC2 {ECO:0000313|Ensembl:ENSLACP00000009395.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009395.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; AFYH01105506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01105507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01105508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01105509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01105510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000009395; -.
DR Ensembl; ENSLACT00000009467.1; ENSLACP00000009395.1; ENSLACG00000008287.1.
DR eggNOG; KOG2122; Eukaryota.
DR GeneTree; ENSGT00530000063749; -.
DR HOGENOM; CLU_001012_0_0_1; -.
DR InParanoid; H3AIC4; -.
DR OMA; FRQMTHS; -.
DR TreeFam; TF106496; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF3; ADENOMATOUS POLYPOSIS COLI PROTEIN 2; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 2.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05924; SAMP; 2.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 30..81
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 648..690
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 1835..2161
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT REGION 266..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1673..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1846..1971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2047..2070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2097..2198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2258..2280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2342..2366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..83
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1675..1689
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1818..1832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1852..1876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1903..1971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2047..2069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2148..2164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2167..2185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2258..2279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2342..2357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2366 AA; 264150 MW; 68AAA269B798829E CRC64;
ISLLDMKNSI YKSYISNQSL EDIRMSGSVS SYDQLVKQVE ALKRENSHLR RELEDNSNHL
SKLENETSDM KEVLKQLQGK LEQEAKTLVS TGRSDVLDQL KELQMDITSL YEFRFQSHVP
NLVQEEGPLP GQVAEGGPTH SGVLQKTKEC GGSKRETIKH LEELDKERYF LLSEIEKEEK
EKLWYYTQLR SLSKRLDELP RIETFSMQMD LIRQQLEFEA RHIHTLMEER FGTSDEMVQR
AQIRATRLEQ IKEELQEAQE KIQQTKLQAR VCGKPNHSET DSIANNPPHI EEPNHLGSKV
EMVFWILSML ATRDKDDMSR TLLAMSSSQE SCVAMRKSGC LPLLIQLLHD MDRDLVVPES
SSATPASRSG CSKDARTQAS AALHNIIYSQ PDEGQAKKEM RVLHVLEQIR SYCETCWEWM
EMYKQGGDDP GKSAAPTPIE PQICQAMCAI MKLSFDEEYR RAMNELGGLQ AVGELLQVDF
EMHGMTNDPL NLALRRYAGM ALTNLTFGDV VNKATLCSKK GCMQAIVAQL GSESEELQQI
LSSHLRVRNK IREVDRISTL LSTSGRYAKE PTLKSLLSAL WNLSAHSTDN KVAICSVDGA
LAFLVSILTY KCQSNSLAII ESGGGILRNV SSLIATREDY RQILRDHNCL QTLLQHLKSH
SLTIVSNACG TLWNLSARSS KDQELLWDLG AVSMLRNLIH SKHKMIAMGS AAALRNLLSN
RPLKYKDAAV ISPGSCMPSL YMRKQKALEA ELDAKHLAET FESIEKQSPK NPSINKPLRH
IENLVKDYAS DSGCFDDDEA PNVSTGLETG SLSVLSMFLN SSFLQGQGMP RGIAQRKCTE
SEVDLNDDEV SLAAEQLANK ISTTVAKIDK LVEDISTMHT SSEDSFSLSS EDHCIDWQYG
SDELHETRAK SCSPCRLSDS STFVKRESLS RAHPLLRLKT AYTSLSNDSL NSGSTSDGYC
TKEQVKPSQR TSFVEYKAEV QMCQKRPDQL DLKSTDEKKE GERNIQNHEC SSEPNITTIK
LSPSYQRVSL TQSFGKGNII SGCPPNMFVQ KQAWLPSNLA QVGETLDKPS QNIAVCTPTL
LEPETAKKFS VEDTPICFSR CSSLSSLSSA DNILDGQSHS ENEIDSDSSL EIIEDKIEDE
QDVTKEISTK PNVSQPIEIP SQKQQKVFIG DSSPSRNEDM TPSSSSENYI QETPLVMSRC
SSVSSLGSFE SPSIASSIQS DPCSEMISGT ISPSELPDSP GQTMPPSRSK TPSFEPIGQP
EKENNQFNIQ WENNIKRFLE IADFKERFQF PPDIDSMIYF TVEKPNENFS CASSLSALPL
HEHYIQKDVE LKLMHSLQEK NCLNFVAHEK AVDILQESAL ERTEKPDSCE CNSDDDIEIL
KECINSAMPS KFRKVKSSLI STLSTHVLNS QTKKSLQLPV YMLVPAQASD DSSFTDSAEG
TPVNFSSAAS LSDETLQYPL KDNTGLKDQK PFISKKLERR DLMPVEGHCT EDIQASSNIG
NLVKTNIGNL VKTKNIQGNT TNMSKIKQNV LSGSYAFQSF CHTTPTEEAV YCFYENESHD
LDLEKDVPDK KTDVHRSVNE DKSKTLTRKE ADQNTRLCMY SKNKNIAGKY KHNLIIDETP
PCYSLSSSLS SLSDMDLEDQ EKTQLCKRGC ERDSSPSSLS LNSEDDLLQK CISSAMPKKR
RHSARKRNAE RKQKNKDWKP DLAHHLSDEN MSDKASDLDS VEWKAIQEGA NSIVNWLHQA
AVSLSREPSS ESDSILSFMS GLSVGSPLRL NFDMKEKKRI QKEVFQKEGN ASRKKEHVRG
SEDKKKEAEK KTNGNRNSRA DKNISQNKQI PNLPVVFRGR TVIYMPKESA SPRSTPKKTA
KNDAFPQNSN QLQQRSRSLH RLEKSTELAD LSLQKRSATP PARISKGPSS GSSRNSTPSR
QPQKKLTSPS QINKQLTGPG TRSNGSIPEK KCNPAVSTTT KKNKTQKSPV RIPFMQTPTK
KVIPQRNNSS PLINQFNRQK QNLNGKNLQP TRLDLVRMSS ARSSGSESDK SGFLRQLTFI
KESSSHILRQ RSEISSSESL SSLSRCASPR KSKSDIPAVF LCSSRCQELK VAKPVMPNHN
VTLSKTTTSS DRKHPKRTSS ESPSRPPVKN NPMQREILKR HSSFPHINMR KRTNSPSVFS
SFSESCDKAK GDVEYKPEQK PRDVNGKQSQ QKSAQGMWRR IRDEDVPHIL KSTLPSSALP
LVNNNKSEQQ LSNKQNVIQR KTSDAVVQTE DFLITKTNSS TSPTLETTPP VSAEASKKIS
TATGGGPVFD CDRETLSCIK NSTATSFVNE STPSGVGPFH SSRHSSPSRA VKVTPFNYIP
SPMATSSQTS QIQVPTMNEK PMEKVE
//
