ID H3AQ45_LATCH Unreviewed; 1363 AA.
AC H3AQ45;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PIK3R4 {ECO:0000313|Ensembl:ENSLACP00000011766.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011766.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000011766.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01148704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01148713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000011766; -.
DR Ensembl; ENSLACT00000011856.1; ENSLACP00000011766.1; ENSLACG00000010358.1.
DR eggNOG; KOG1240; Eukaryota.
DR GeneTree; ENSGT00390000016225; -.
DR HOGENOM; CLU_001696_0_0_1; -.
DR InParanoid; H3AQ45; -.
DR OMA; ATNTCRI; -.
DR TreeFam; TF102034; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000010358; Expressed in pharyngeal gill and 5 other cell types or tissues.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 26..323
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 462..492
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 990..1031
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1330..1363
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 836..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 153663 MW; C64E56DB18E149C9 CRC64;
MGNQLAGIAP SQILLVDSYF SDIHDFEYDR SLGSTRFFKV ARAKHREGFV VVKVFAIQDP
SLPLTTYKQE LEDLKIKLQF AQNCLPFQKA TLSEKAAILF RQYVRDNLYD RISTRPFLNN
IEKKWIAFQI LNAVDQAHKA GVRHGDIKTE NVMVTSWNWV LLTDFASFKP TYIPEDNPAD
FNYFFDTSRR RTCYIAPERF VDGSMFTTEL ECSKDPTTPL VDLTNNNQRT RGELKYAMDI
FSAGCVIAEL FTEGVPLFDL SQLLAYRKGH FSPEQVLKKI EDINVRHLVT QMIQREAERR
LTAEKYLLQQ RGNAFPEIFY AYLQPYMAQF AKDTFLSADE RILVIRKDLE NIIHKLCGND
QTEKMEGETK EHGLVILVSV ITSCLQTLKY CDSKLAALEL ILLLASRLSV ELLLDRITPY
LLHFCNDSVP RVRAEAVRTL TKVLALVKEV PRNDINIYPE YILPGIAHLA QDESTFVRLA
YAENIALLAE TALRFLELVQ LNNLNVENEV HAEETEEALH PNGNYDTELQ ALHEMVQQKV
VTLLSDPENI VKQTLMENGI TRLCVFFGRQ KANDVLLSHM ITFLNDKNDW HLRGAFFDSI
VGVAAYVGWQ SSSILKPLLQ QGLSDAEEFV IYKALNALTC MCQLGLLQKP HIYEFSSDIA
PFLCHPNLWI RYGAVGFITV VAQHLNIADV YCKLMPFLKP FITHPIIQID KELVLLSVLK
EPVSRSIFDY TLRSKDIGSL FRHLQLRQRK RNGTIPDCPP PEDPAIAQLL KKLLSQGMTE
AEEDKLLALK DFMLKSNKAK ANVVDHSHLT DSSQKGVIDL AFLGMMGRQV DLVKVKQEPD
DKRAKKHGRQ DSNMNEEWKS MFGSLEPSGI TQAVPKVLVP PTEQEGTGKP LRSESSPGIL
APTSSLPQIP GVEKSTSSLP TQQTLSRTTL PSTYQRRITT CKTELQHLVQ QKREQCSAER
IAKQMMESAE WESKPPPPGW HPKGLLVAHL HEHKSAVNRI RVSDEHSIFA TCSNDGTVKI
WDSQKMEGKT STTRSILTYS RIGGRIKTLT FCQGSHYLAL GSDNGTIQLL GIEASKPPKS
PKIQPLQCRS LDQKDDGCVV DMHHFNSGAQ SVLAYATVNG CLVGWDLRSS TNAWTLKHDL
RLGLITSFAV DIHQCWLCVG TSSGTMACWD MRFQLPISSH SHPARARVRR LLMHPLYQSW
VIAAVQGNNE VSMWDMETGD RRFTLWASTA PPLSEMQPSP HSVHGIYCSP ADGNPLLLTA
GSDMRIRFWD LAYPERSYIV AGGANDALHC PSVSYYRKII EGTEVVQEIH SKQKIGTSDD
TPCKGPESLP IGHHDIITDI ATFQTTQGFI VTASRDGIVK VWK
//
