ID H3AQR4_LATCH Unreviewed; 338 AA.
AC H3AQR4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=methenyltetrahydrofolate cyclohydrolase {ECO:0000256|ARBA:ARBA00012776};
DE EC=3.5.4.9 {ECO:0000256|ARBA:ARBA00012776};
GN Name=MTHFD2 {ECO:0000313|Ensembl:ENSLACP00000011985.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011985.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000011985.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-
CC formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57455,
CC ChEBI:CHEBI:195366; EC=3.5.4.9;
CC Evidence={ECO:0000256|ARBA:ARBA00036357};
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DR EMBL; AFYH01172407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01172408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01172409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01172410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01172411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01172412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006006556.1; XM_006006494.1.
DR AlphaFoldDB; H3AQR4; -.
DR STRING; 7897.ENSLACP00000011985; -.
DR Ensembl; ENSLACT00000012076.1; ENSLACP00000011985.1; ENSLACG00000010548.1.
DR GeneID; 102351616; -.
DR KEGG; lcm:102351616; -.
DR CTD; 10797; -.
DR eggNOG; KOG0089; Eukaryota.
DR GeneTree; ENSGT00940000164825; -.
DR HOGENOM; CLU_034045_0_1_1; -.
DR InParanoid; H3AQR4; -.
DR OMA; VCHILTK; -.
DR OrthoDB; 5386942at2759; -.
DR TreeFam; TF323998; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000010548; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_01576; THF_DHG_CYH; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099:SF15; BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00766; THF_DHG_CYH_1; 1.
DR PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 36..151
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 154..326
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 338 AA; 36591 MW; 49402C6595858F73 CRC64;
MSPSSSFRAL RSLCQVMHAH VCQLHLSAAR HEAVVISGRK LARQIRNEAK DEVEQWVAAG
NKRPHLSVVL VGDNPASHSY VLNKTKAAAD VGISSETILR PASITEDKLM DLINSLNDDR
NVDGLLVQLP LPEHLDERKI CNAVSPVKDV DGFHVVNVGR MCLDQYSMLP ATPWGVWEII
KRTGIPTLGK NVVVAGRSKN VGMPIAMLLH TDGRHERPGG DATVTISHRY TPKDQLREHT
KLADIIVAAA GIPNLITADM IKEGAAVIDV GINRVQDPVT GKPRLVGDVD FEGVKKKASY
ITPVPGGVGP MTVAMLMKNT IIAAKKLLRT KEQLANAA
//
