ID H3AT55_LATCH Unreviewed; 355 AA.
AC H3AT55;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Urotensin-2 receptor {ECO:0000256|ARBA:ARBA00014302};
DE AltName: Full=Urotensin II receptor {ECO:0000256|ARBA:ARBA00032764};
GN Name=LOC102349113 {ECO:0000313|Ensembl:ENSLACP00000012826.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012826.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000012826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The
CC activity of this receptor is mediated by a G-protein that activate a
CC phosphatidylinositol-calcium second messenger system.
CC {ECO:0000256|ARBA:ARBA00025579}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AFYH01140579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AT55; -.
DR STRING; 7897.ENSLACP00000012826; -.
DR Ensembl; ENSLACT00000012920.1; ENSLACP00000012826.1; ENSLACG00000011295.1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000157017; -.
DR HOGENOM; CLU_009579_1_0_1; -.
DR InParanoid; H3AT55; -.
DR OMA; HRSFYRY; -.
DR TreeFam; TF334200; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001604; F:urotensin II receptor activity; IEA:InterPro.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR CDD; cd14999; 7tmA_UII-R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000670; Urot_II_rcpt.
DR PANTHER; PTHR24230; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24230:SF53; UROTENSIN-2 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00647; UROTENSIN2R.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..296
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 355 AA; 40806 MW; 162FB8D1DC6DD2D7 CRC64;
NLTWNGSTSG EPANSSSMDE LIITSAFGTI LSFMYVAGVT GNVYTLVVMC NSMRYAASMY
VSIVNLALAD LLYLSTIPFI VCTYFVKDWY FGDIGCRILF SLDLLTMHAS IFTLTVMCTE
RYLAVTKPLD TVKRSKSYRK AMAGAVWLIS LLLTLPMMIM VNLDESRRGN GIKRICAPTW
SPEAYKIYLT VLFSTSIMAP GVIIGYLYAR LARTYLESQR NTLSKRENKR SPKQKVLIMI
FSIVLVFWAC FLPFWIWQLI RLYDRPIKLA SQTQTCINYL VTCLTYSNSC INPFLYTLLT
KNYREYLKNR HKSFYRYTSS FRKRNSNQQS SWGKSNSYSN QYDYISESIV MSSLK
//