ID H3AU93_LATCH Unreviewed; 2829 AA.
AC H3AU93;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
GN Name=VWF {ECO:0000313|Ensembl:ENSLACP00000013214.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013214.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000013214.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; AFYH01149050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000013310.1; ENSLACP00000013214.1; ENSLACG00000011635.2.
DR GeneTree; ENSGT00940000155810; -.
DR HOGENOM; CLU_000076_5_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000011635; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 5.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF361; VON WILLEBRAND FACTOR; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 3.
DR Pfam; PF00092; VWA; 3.
DR Pfam; PF16164; VWA_N2; 1.
DR Pfam; PF00094; VWD; 4.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00327; VWA; 3.
DR SMART; SM00214; VWC; 7.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57567; Serine protease inhibitors; 5.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50234; VWFA; 3.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 3.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 30..198
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 383..557
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 862..1029
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1269..1441
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1489..1655
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1698..1881
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1958..2136
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2271..2344
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2445..2511
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2597..2662
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2741..2829
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 2741..2791
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2756..2805
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2767..2821
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2771..2823
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 2829 AA; 313073 MW; CCBBD7122271481B CRC64;
MNKCKMKLCD DLQLCLIFLV LTAGVLKMVS HCSLFGDYHI QTFDGTFYDF PGDCSYKLAG
DCQKRSFSIL GDYQNGKRKS ISLYLGEYFD IHMLLDGTVI QGDKRISLPY ASSGIFVETE
TGYYKLSSEE YGFTVRIDTS RNVHILLSER HFNKTCGLCG NFNNFAEDDF IAQEDFLAEN
SYDFANSWAL HGAEKPCKRV SPPSKTCNIS LWIADEDLMA KCQVLKTASV FLKCHHHVDP
EPFIALCEED MCKCGEEREC HCQAILEYAR TCAQQGIILK GWPSESSCNL KCPFGMEYYE
CVSPCTKKCQ SLNINEVCQE QCIDGCSCPV GKVLDGDQCV EASECSCTHK GKHYPPGSSI
SQDCNTCVCR HGAWVCTNED CPGDCFVTGQ SHFKSFDNKY FTFSGVCQYL LAKDCQDNSF
AVVIETVQCA DDPDSVCTRS ALIRVQELVN STIKLKHGGA VSLDGQDIQT PLMHGAVHIQ
HTVMASVRLT YKEDLQIDWD GYGKLLLKLG PTYSSKICGL CGNYNGNQKD DFLTSSGLIE
AHVEDFGNSW KLNGDCLDVV KQDSDPCSLN PKRARYAEEL CSVLMSAEFE PCHHEVNPAP
YVKNCRYDVC ACSDGKECLC SAVSTYATAC SRKGVLINWR TSNFCAMKCS KDQVYQLCGT
PCNQTCRSLS FPEPACKEVC MEGCYCPPGL FAMEDGECVP RSQCACYYDG EIYQPNDVFS
NHFTICYCEN GVMHCSTKDA SNALFPDLFL DYSLSARVKR SLTCKPPLNK FVCPPSNPRA
EGIECTKTCQ NFDLECVSQG CISGCMCPQG WVRHKNKCII PEKCPCFHSG REFAQGSSVK
IDCNTCVCHN RKWECTENVC DGSCKTIGEA HYLTFDGMKY TFPGYCQYVL VQDYCSNHDG
TFRILLENDG CGLLGEKCSK HITVLYDGGE IELSNRKVKI IKPLRDESDL EILRSGQYFI
LMLGKGISIT WDLTTRVTVH LKQYYRGKVC GLCGNFDGIH NNDLLSSNNQ LEVDPVNFGN
SWKVNSGCAD VSEFPSLCNG NVFKQVAVEN SCNILVSDIF QECTQLIDPE PYWEICTYDT
CACESIGDCA CFCNAVAAYA QECTQQGIIV QWRSNNLCPL SCQEKNKAEP EYECEWRYNA
CAPACPVTCQ HPEPLDCPLN CVEGCHAYCP PGKILDEDSE KCIDPAECSV CIHEGRHIPH
GKMIILNRED PDHCQRCHCE GTNLSCSPCS KDMTTLVPVV SSTTTTTTTT ATPEHTVMVP
ENVCSKMMDL AFMVDGSSKL SEEDFNTLKS FIVTIMEQLH IGQNKIRVAV LQFHSGIQKY
FGLQEKKSPP ELRKIVEDME YSGAEAAFIG EALKYAALYV FGKAPRKNAP KIGILLTAST
SPRKFDSALG LASRKKMTII PIGVGPFISR SQIKLITSQS PSSQAFIMDN VDELKDHASE
IIRYLCGLGV VPTAKPLKVA TTAVPAITTS HTTSPPLTLS TSPAKRIKDI VIVIEGSDKV
GENNFIETKK FVEEVVRRLN VGTETTHITI MQYSTTVTTE YTFTESQSKH DILERIKKIE
YHGGSATNTG RALQHVTQTT LIESNGARDQ VPHLVFMVTS NPSSDVITRI SKNTEIIPIG
VGPNVNITEL DLISYPNKPT LVDGYEKLTT IVHTLLESCC EIETRSMTVS PQVITTLKPA
AVTLAPLPPA VPCDEPMDIV VLLDGSTNIM EPQFEEMKTF VKELIKKVDI DPGNNGTQIS
VVQYGKTNTL EISWTDLQNK ESLLDKVDAI QQRQAGLSRI GEALTYALLN TVPEARGGRP
GVQKIAVILV TEQSTDNIEN AAYTASVDRV TVFPIGIGKN YDVKQLETLA GEFNQGNIIH
LNRVEDLPTM VTLDYGFINK LCKGTNKVCL DDDGNKRKPG EKWMLPDKCH SVTCLPGGQT
SVQSHKINCD KLSKPVCRNN LPSIKVEETC GCRWSCPCMC MGSSTKHIVT FDGLAFKLTG
NCSYMLFNDK EHDTEVILHN GPCHFVSNAM HNCMKSIEVK HKKTSVQLFD DMKVTVNGEV
RLTPFTTGEI ESVLYGAIMH EAKIPGIGFV LTFTPKNNEF TIQLSPLFVA KTSGLCGICD
QNDMNDFMLR NGSVTPDSNT FIKEWTMQDS PDRICEMPVI EACTGTTPVS DECNILLSPL
FEQCRKVVPH LPFFSLCKEN SCHGEEICEI IAAYSLMCRL QGICTSWRSP HFCAMQCPSS
LEYDYCRKGC TKQCESSANI TQCPDSPTEG CFCPEGKVFF NGECANEDVC TQCIDENGTP
RQVMETWIPS HEHCQICTCL DNRRINCTTK PCATATPPTC GPCEIPRLTN DAHQCCPEFE
CVCDLVTCVL PPVPKCEDGL VPVLTNPGEC KPNYACACKK EECKLESAPS CSSHRKRTVE
KTQCCDKYEC TCNCVNSTVS CPLGYSSESV TNDCGCTTTT CNPDKVCVHH EVIYHTGHSW
EENCKECTCT NEKDSITGLY IAECFEKTCS EICPPGETYT KEEGECCGKC KKANCQEVAF
GTDGQEINHW HVVGDIWRSS LNPCLINECN MVNGEAFVQQ KNVSCSHLKV PKCPTGFELQ
CNRVEDCCPT CECIPVNGCV LNGTIVGAGK TVIMDACNEC ECRVENDMIT KFQLRCKKTT
CKPCPDGYIA EKINGSCCGK CKPTVCSVKL KSGRIVKLKP NETIQDGCDS NHCKVNDQGE
FVWEKRITSC PPFNREKCLA GGGKIAQITE TCCERCVEAE CKQVTGVIKT IMIDDCVTEN
NVNIHYCEGK CTSKAVYSLE KEKMENQCIC CSATATEPMK VPLRCGNGTI VQHEVLNAKQ
CDCLSHECE
//
