ID   H3AX00_LATCH            Unreviewed;       607 AA.
AC   H3AX00;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Glycoprotein nmb {ECO:0000313|Ensembl:ENSLACP00000014171.1};
GN   Name=GPNMB {ECO:0000313|Ensembl:ENSLACP00000014171.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014171.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000014171.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC       {ECO:0000256|ARBA:ARBA00025776}.
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DR   EMBL; AFYH01080484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01080485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01080486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01080487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3AX00; -.
DR   STRING; 7897.ENSLACP00000014171; -.
DR   Ensembl; ENSLACT00000014270.1; ENSLACP00000014171.1; ENSLACG00000012475.2.
DR   eggNOG; ENOG502QVWX; Eukaryota.
DR   GeneTree; ENSGT00950000183188; -.
DR   HOGENOM; CLU_017264_0_0_1; -.
DR   InParanoid; H3AX00; -.
DR   OMA; HGWRKWN; -.
DR   TreeFam; TF334865; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000012475; Expressed in pectoral fin and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR045219; PKAT.
DR   InterPro; IPR046846; PKAT_KLD.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR   PANTHER; PTHR11861:SF11; TRANSMEMBRANE GLYCOPROTEIN NMB; 1.
DR   Pfam; PF20433; PKAT_KLD; 1.
DR   Pfam; PF00801; PKD; 1.
DR   SMART; SM00089; PKD; 1.
DR   SUPFAM; SSF49299; PKD domain; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..607
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003579583"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          287..324
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          342..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   607 AA;  67766 MW;  4707D2E21CDB34D7 CRC64;
     STCLLLPMLI PALGMFSGNQ FYKGFRDAMP SGRSQLLARS HVSSVRNHQT LQGWQSDNNT
     WNENLYPIWK TNDSKWKNYW RGGKVIAHLT SDSPALVGSN VTFSVTLQFP RCQKENKNGD
     LVYDDNCKSD SSVFPGEFVY NWTSWLEQYG WGVCSNILRC NVFPDGKPFP FHHDWRRRNF
     VFVFHTLGQY YQKTSSSSAT ISLNTMNITL GTHLMEVAVY HKRRYRNYIP VATVTTLFDV
     TDVDKIPFFV QISQKNDVNI FDKVFIKDLK VIFDVRIHDP SNYLKNSNVS YKWDFGDSRR
     LASNSSVVTH TYTRVGKFHP QLTIRAIIPV PCGPVTQTPF PFTSESTTAS ATTTEQMTSQ
     TTRDPTTMTS QTTPSIPTSA ATETSTETKT SLPTARFPQP AGCQLYRYGQ YNTSLIIVEG
     ITSVSIVQVT SVVEVSASQV TNAIMEFVVT CQGGKKKKNS IPTDVCTIIL DFSCTTTKDV
     FCDSVPPADK CQLTLQRAFN QTEPFCVNIT LSDGGSLAAT STLVSIGKAT RNTMLEAVLI
     VGGFLGFLVI IIAAVYYKRY KAYTPVDGNG QNVVHLEGLS VYFNRLKAIL LTGNEEQNLL
     LKETTGI
//