ID H3B007_LATCH Unreviewed; 373 AA.
AC H3B007;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=G protein-coupled receptor 45 {ECO:0000313|Ensembl:ENSLACP00000015228.1};
GN Name=GPR45 {ECO:0000313|Ensembl:ENSLACP00000015228.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015228.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01089548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B007; -.
DR Ensembl; ENSLACT00000015334.1; ENSLACP00000015228.1; ENSLACG00000013407.1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_9_1; -.
DR InParanoid; H3B007; -.
DR OMA; IKVDMSF; -.
DR TreeFam; TF338633; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15403; 7tmA_GPR45; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24245; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24245:SF4; G-PROTEIN COUPLED RECEPTOR 45-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..325
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 373 AA; 42426 MW; A9118F2055E95D2C CRC64;
ISCNSTLIEE CALGPLNITS VSVDASFTAF PIALRILLAI VMMCMIAIGF LGNAIVCLIV
YQKPAMRSAI NLLLATLAFS DIMLSLLCMP FTAVTIITTN WHFGAYFCRV SAMLYWFFVL
EGVAILLIIS VDRFLIIVQR QDKLNLHRAK IMIAISWGIS FCISFPSVVC WTIVEVPARA
PQCVLGYTEF PADRVYVVLL VVSVFFIPFS IMLYSYLCIL NTVRRNAVRI HNHADSLCLS
QVSKLGLMGL QRPHQMNVDM SFKTRAFTTI LILFIGFSVC WLPHTVFSLL SVFSRRFYYS
PSFYTISSCV LWLTYLKSVF NPVIYCWRIK KFREACMEFM PKTFKILPKV PGRTRRRIRP
STVYVCSEQQ SAV
//
