ID H3B299_LATCH Unreviewed; 722 AA.
AC H3B299;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=NOP2/Sun RNA methyltransferase family member 7 {ECO:0000313|Ensembl:ENSLACP00000016020.2};
GN Name=NSUN7 {ECO:0000313|Ensembl:ENSLACP00000016020.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016020.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016020.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; AFYH01106803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006000032.1; XM_005999970.2.
DR AlphaFoldDB; H3B299; -.
DR SMR; H3B299; -.
DR STRING; 7897.ENSLACP00000016020; -.
DR Ensembl; ENSLACT00000016131.2; ENSLACP00000016020.2; ENSLACG00000014107.2.
DR GeneID; 102345320; -.
DR KEGG; lcm:102345320; -.
DR CTD; 79730; -.
DR eggNOG; KOG2360; Eukaryota.
DR GeneTree; ENSGT00940000157352; -.
DR HOGENOM; CLU_023514_0_0_1; -.
DR InParanoid; H3B299; -.
DR OMA; QIPTQHF; -.
DR OrthoDB; 5312486at2759; -.
DR TreeFam; TF314285; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR049561; NSUN5_7_fdxn-like.
DR InterPro; IPR042620; NSUN7.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14663:SF2; METHYLTRANSFERASE NSUN7-RELATED; 1.
DR PANTHER; PTHR14663; UNCHARACTERIZED; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF21148; NSUN5_fdxn-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 204..518
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 543..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 449
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 363
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 722 AA; 81350 MW; CD85B0A929C1D214 CRC64;
MEKMQTSKSE IELELTESGP LLELLELEDV GIIVRRLSEK SASNLCEIPS YSDSVFMNAA
KLYQKNHAEK PIDQRLVNYG DDPGLAVPNI KNKTSQRWAY ELAFNALKYQ TILEDIMIDS
CLYQSQLISD EMSSLAIVML YDFQNRKFKP RAILDYKEDI IPEVREVENC LHSFKTKLAA
ALARCRIKRD VLSIDCILPE SLRTQQQRAS ILPLYTWVNI LKTSIELVCQ TLEQEGFSKV
NSLSELNGYS FCQDLHCPNV LIFPAHLNAE FSENDLFTEY KVIMQDKSRS LAPHSVKALM
NMDDDIMISN LGSGMTAAHM STLTNQKTCK VFVCGVKSEI QKLEMNNIFA QMECKNIKLM
HEDFIDIDPT DPRIQKVKII LLLPQCSGSG VSNPIEFILK EHGDVGILQD FSQGSIAEDK
LNLLVEQQLQ DVLHAQKFHK VQAVVYCTCS VYPEENEDIM KKALTYNVEG NKVQPYRICP
PVLPLCSASE IMSSADKFFR LKPSEIANGC FLAILTRERD PSGIVSVKDV LARAAAKGLL
EGIEMGKSQK REKRKKSKPS IQRTSSNTSG TQAKIAEFLT KEMKKESNAN SNVSKPIGRQ
SSLKILKQTS ATVTRRTSKT IPVPPESNVT RRHTIGTILP VHKYSSIMKQ QDEKLLPMKP
VHIGLPPCPS ATKLKMRSPS HSYWNPETSV VRRSLGSIPS VLLKKSKGSY IFDSTRHSRP
WH
//
