ID H3B358_LATCH Unreviewed; 517 AA.
AC H3B358;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016329.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AFYH01051023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B358; -.
DR STRING; 7897.ENSLACP00000016329; -.
DR Ensembl; ENSLACT00000016443.1; ENSLACP00000016329.1; ENSLACG00000014387.1.
DR eggNOG; KOG0166; Eukaryota.
DR GeneTree; ENSGT01050000244891; -.
DR HOGENOM; CLU_018084_6_1_1; -.
DR InParanoid; H3B358; -.
DR OMA; IMIKECG; -.
DR TreeFam; TF101178; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014387; Expressed in pectoral fin and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF12; IMPORTIN SUBUNIT ALPHA-1; 1.
DR Pfam; PF00514; Arm; 5.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 2.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..59
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 249..291
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 517 AA; 56585 MW; 5059DA463088FF59 CRC64;
HTKMSSENAS VRLNRFKNKG KDTTEMRRRR FEVNVELRKA KKDEQIFKRR NVNSFPGEAI
SPLQEKSQNC QGPSHWTVEE IVNGVNGNNL ELQLQATQAA SKLVVAEKPA PMQDGVLGGA
SAVFYEWNSS TCLTPPTFAL QGGYLAVILK HSTFLELRLD HFKTPVSLLL ISAVAIFQTI
NHTCVHFIGD GSACRDNVIK LGATEPLLAL LAVPELSALS CGYLRNLTWT LSNLCRNKNP
APPLDAIQQI LPALVRLLHH DDKEVLADTC WALSYLTDGA NDRIDLVVKA GVVVRLVQLL
GCNELPIVTP SLRTVGNIVT GTDEQTQLVL DAGVLAVFPS LLSHHKNSIQ KEAAWTISNI
TAGCQDQIQL VVNSGLVPYL IEILKKGDFK SQKEAVWAVT NYTSGGSINQ IVYLVQSGAV
EPLLNLLSAK DSKTVIVILD AITNIFLVSC MCVAFFGGGG KNKVVFTLKI VQTHKVKASL
IRDHTYEEED DLSVVPDSTS EGYTFQIENP SPGTFNF
//
