ID H3B494_LATCH Unreviewed; 137 AA.
AC H3B494;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Pleckstrin homology-like domain family A member 2 {ECO:0000256|ARBA:ARBA00040374};
DE AltName: Full=Imprinted in placenta and liver protein {ECO:0000256|ARBA:ARBA00041856};
GN Name=PHLDA2 {ECO:0000313|Ensembl:ENSLACP00000016715.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016715.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in regulating placenta growth. May act via its
CC PH domain that competes with other PH domain-containing proteins,
CC thereby preventing their binding to membrane lipids.
CC {ECO:0000256|ARBA:ARBA00037121}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the PHLDA2 family.
CC {ECO:0000256|ARBA:ARBA00038385}.
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DR EMBL; AFYH01085723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005997638.1; XM_005997576.2.
DR AlphaFoldDB; H3B494; -.
DR STRING; 7897.ENSLACP00000016715; -.
DR Ensembl; ENSLACT00000016831.1; ENSLACP00000016715.1; ENSLACG00000014725.1.
DR GeneID; 102360917; -.
DR KEGG; lcm:102360917; -.
DR CTD; 7262; -.
DR eggNOG; ENOG502RXZA; Eukaryota.
DR GeneTree; ENSGT00440000039564; -.
DR HOGENOM; CLU_062639_1_0_1; -.
DR InParanoid; H3B494; -.
DR OMA; CWHAEIT; -.
DR OrthoDB; 3911764at2759; -.
DR TreeFam; TF332320; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014725; Expressed in pectoral fin and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00821; PH; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042832; PHLA1/2/3.
DR PANTHER; PTHR15478:SF8; PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2; 1.
DR PANTHER; PTHR15478; PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 11..106
FT /note="PH"
FT /evidence="ECO:0000259|SMART:SM00233"
SQ SEQUENCE 137 AA; 15882 MW; 19A23759C9E9A4F9 CRC64;
MKMSAIEVPQ VIKEGELEKR SDTLLQLWKK KTCVLTKESL NIFADIQKKS KCKEMKFQSI
KKVDCVERSG KYVFFTIVTT ENKEIDFRCL ADSCWNAAIT MALIDFQNKK AIQDFKSRQE
TEVASQGRQE RHLARSP
//
