ID H3B5B8_LATCH Unreviewed; 1721 AA.
AC H3B5B8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Laminin subunit alpha 4 {ECO:0000313|Ensembl:ENSLACP00000017089.1};
GN Name=LAMA4 {ECO:0000313|Ensembl:ENSLACP00000017089.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017089.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017089.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; AFYH01030164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000017089; -.
DR Ensembl; ENSLACT00000017214.1; ENSLACP00000017089.1; ENSLACG00000015059.1.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000159970; -.
DR HOGENOM; CLU_002814_0_0_1; -.
DR InParanoid; H3B5B8; -.
DR OMA; AVRCMCK; -.
DR TreeFam; TF335359; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015059; Expressed in pelvic fin and 5 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF02210; Laminin_G_2; 5.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 30..85
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 86..139
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 943..1123
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1130..1298
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1367..1538
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1545..1718
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1308..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..432
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1308..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 56..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 111..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 123..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1721 AA; 191287 MW; EAE09837E7BAF99C CRC64;
NCRHNTAGDH CERCLEGFIA LVWSTSCEPC PCPLSTNSNN FAVSCANRGG TVRCVCQDNY
AGPSCERCAP GYYGNPLLIG NSCQKCNCNG NSDPNLIFDD CDEVSGHCRN CLRNTTGVNC
ERCATGYYGD AIVAKNCTGC DCGGGPCNSR TGECLPEDTE PPATTDCTVV SKEVCNWSAS
SKKLLILACI QGSTSILFIQ SGTRSDILKR DYRIQTQIPE WINSSVYRKF QVVEVETKIT
TLQSDLDTLE KQESSTLTKG RNVERKTLET VRHAEQIVKQ ASSLNTSIQE IITQLKFYGM
AHELSQHDIA KRLIKAEKML REMKQKNFTS QKQLAEKESG KADKLLDHVG QFEFWHNGTR
SLIPSLLSQL SEYSTNLSDV KELLQEANKN IKEAEDKNKD IAVRFREHEN AKSELEEQHE
AASEIIKMAE VMLVDTELAV AEMDNMIQNV SEFHAAIDGS IKLLRERLTN LSTYDKDLVL
RAFDFAKELQ SLAAKMESHL KKIDTNGFVQ KAINASNVYE NIATYIEEAN KTALFTLSAA
NRTKDAITGI STQLGFLKDK SERLLNQAKA SQESAEARKA LTVEDTRNRL KGVINKKDEL
KGGLSKAIGQ LQLLQQGNTR EQSERASLIA EEANSTSALV TQTVAPINKY VNEWAQNLED
SKDDISDYSK AVKAAGDTVN NLTEIVPQLL DKLRIIEQKQ PHASNLSVNI LRIRELIAQT
RSVASKVQVA MKFDGQSSVE VRPKINLEDL KASSSLSLYM KPSPANQPVQ TSTQDRCVLY
LGSKNAQRDY MGLAIKNDNL VYIYNLGSGD VEIPLSSKPI STWPAYFTLV KIERVGKYGK
VFLTVPNPSS TAEEKFVKTG KAPGVDSLLD LDPDNTVFYV GGVPSDFRLP VSLNLPNYVG
DIELATLNDN IISLYNFKQL HNMDTAATPP SARYKLAFTQ SRAANYFFDG SGYALVSNIE
RRGKFSQVTR FDVEVRTPAD NALLLLMVNG SMYFSLQMQD GYLIVHYDFG FAKGPVVLED
NLKKAQINDA KYHEISVIYH NSKKMILVVD RRHVKSVESE KKAMPFTDIY IGGVPSELLT
PSILRSNLAV DVGFRGCIKG FQFQKKDFNL LEEPGSLGIS SGCPEESLMS RTAYFNGESF
IASSQKIFPF ENFEGGFNFR TLQPSGLLFH YDEGADVFSV ALDNGSVVFN MKGTTLKSGG
KEYSDGQNHF IVTSVTPESC QLVVDDKDKQ HKDLPTSGKR EQNPATNNKF YFGGSPSSQY
SNFTGCISNA YLTKVDRDVE VEDFQRYTEK VQVSLHDCPV EKPPAALVSK HERNSVKSKE
GRKTKAGRAK GNIPQLPVGL KHVYEGSNPK ELSQCYLSLR PTATQHAYQY GGTPNSRQEF
NSIPESFSER SHFSISLRTR SSHSLIFYVA DEWEDNFMAL FLAHGRIVYM FNVGHQKLRI
KTQEKYNDGL WHNAIFMREK NKGRLIVDGI KVLEQSLDVN DAPWHVRKPF YVGGVPPRKA
VKNIQLNSVQ SFSGCLRNFQ LDGQWISSAS QAFGVTPCFE GAMELGTYFS AEGGYLVLDD
SFNLGLKFEL VFEVRSRNSS GILLHVRSPN SEYINLHMKH GQVVVEVYNG MHEFATTVTP
KQSICDGKWH RIAVIRDSNV VQLDVDSEVN HVVGPLSPRA IHDKEPVFIG GVPESLLSSR
LEIRNSFTGC IRNFIIDESP VSFSKAALVS GAVSINSCPA A
//
