ID H3B6T0_LATCH Unreviewed; 517 AA.
AC H3B6T0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 3 {ECO:0000313|Ensembl:ENSLACP00000017601.1};
GN Name=ENTPD3 {ECO:0000313|Ensembl:ENSLACP00000017601.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017601.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR EMBL; AFYH01057957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B6T0; -.
DR STRING; 7897.ENSLACP00000017601; -.
DR Ensembl; ENSLACT00000017731.1; ENSLACP00000017601.1; ENSLACG00000015504.1.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263542; -.
DR HOGENOM; CLU_010246_2_3_1; -.
DR InParanoid; H3B6T0; -.
DR OMA; GNAISDM; -.
DR TreeFam; TF332859; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF38; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 187
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 227..231
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 517 AA; 57638 MW; 5D2295A80A31530B CRC64;
LICSTSEILT EKAAKSRIGS KMGSKAPVIA ASVLLLVSVV VIITIAAVQI NKKQIVPPGL
KYGIVIDAGS SRTTVYVYSW PAEKENNTGV VKEAYKCNVT GPGISSYASN PPKAARSLEA
CMNETKKIIP VPLHKDSPVY LGATAGMRLL KLQNETAANA VLSSIEDYFK FLPFDFRSAR
IITEQEEGVF AWITANYFLD NFLEKNVWNA WVRRDGSETV GALDLGGAST QIAFIPKEPT
EGLNSTVMVT LYGYQYEVYT HSFQCYGKNE IEKRFLAILV QTSLSVSMVD NPCYPRGYHV
SFMMGNIFQS LCTESQRPEK YNPEQTVTFV GTGDPAVCKE KVSLVFNFPS CDRKENCSFD
GVYQPSINGK FVAFAGFYYI TEALNLTGKF PLDTFNSTVW SFCSQNWIKL QAILPNAEEK
YIRSYCFAAN YIYNLLVRGY KFDSETWPQI SFQRNAGNNS ITWSLGYMLN LTNMIPAEGQ
LIHLPMTVSV FVGLLFLFVA LAILCLMFLI ISVIRQY
//
