ID H3B7M4_LATCH Unreviewed; 899 AA.
AC H3B7M4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Rho guanine nucleotide exchange factor 26 {ECO:0000313|Ensembl:ENSLACP00000017895.2};
GN Name=ARHGEF26 {ECO:0000313|Ensembl:ENSLACP00000017895.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017895.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017895.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01073780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005996530.1; XM_005996468.2.
DR AlphaFoldDB; H3B7M4; -.
DR STRING; 7897.ENSLACP00000017895; -.
DR Ensembl; ENSLACT00000018025.2; ENSLACP00000017895.2; ENSLACG00000015766.2.
DR GeneID; 102355212; -.
DR KEGG; lcm:102355212; -.
DR CTD; 26084; -.
DR eggNOG; KOG3523; Eukaryota.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_012820_2_0_1; -.
DR InParanoid; H3B7M4; -.
DR OMA; DRDGQKT; -.
DR OrthoDB; 12272at2759; -.
DR TreeFam; TF316357; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015766; Expressed in pelvic fin and 1 other cell type or tissue.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 463..647
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 679..806
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 814..878
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 21..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 102198 MW; FA8B5F6DEDFE1B5E CRC64;
MPSLWSSSVH CSETFEDIME GESEVDLSNN NIIPPWKMRR STPQPGASEN MNQNRKARPP
SYQSSNRVLV TDFPVEDKRL FTVTQPAEKI VASPDNKNVQ RNVSVNASLS PHIVLNSCRG
SVPNGNIASS ENNSVAQRRV SDHSPHTLNM VLNTSVGSLP NINVTSSENK MTIERRISSQ
LSLSPENQQI AFGLNPGLVA NMNHPTIQMQ ASLLPQTPNT VSISPGNSPV VKTPSTGNKM
GLQRQASNHS QTSEKCPIVL STESRVSFKT GMQQIIPKGL ASEIKTTNKN RQNLDSNRRN
FKARSMMETP SAPILSAADV DKDVDTELES PLRRGLRSTS YRRAVVSGIE FDDTSCVRKT
HRMSQPNLKA VVEDKERFYS LGKIKKKEVK RQDMFEGEEH AVLYQNYKEK ALHNDSDEDT
EAKEQKGDEK IIVQYKPLQS TWSQLSTVKK NGISKKISQE EKKRQEAIFE VISSEHSYLH
SIEILIRMFK DSKELSDTMT KTERHHLFSN ITDVFEASKK FLKELDARHQ RNVLMDDISD
IVERHAMSTF DPYVKYCSNE VYQQRTLQKL LGTNPSFKEV LSRIESHSDC RNLPMISFLI
LPMQRVTRLP LLMDTICQKT PEHSAKYETC KDALKSVSKL VRQCNEGARR MERTEMMYTI
NKQLEFKIKP FPLVSSSRWL LKRGELTAFV EDTGIFSKRT SRQQVYFFLF NDVLIITKKK
SEESYNVTDY ALRYQLSVDQ SDTDVFNQSP VKASQGIIPS RQNSVIYLFM LNILKNHAGD
KVKMLLGAES SSDRARWTTT LGLSSNDRQS TDRTKLTQVE ITRTYTAKQP DELSLQTADV
VLVYQKVNDV HSGWYEGERL RDGERGWFPM ECAKEITCQA TIEKNMQRMG RLLGLETNV
//
