ID H3B9L1_LATCH Unreviewed; 1131 AA.
AC H3B9L1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Nuclear export mediator factor {ECO:0000313|Ensembl:ENSLACP00000018582.1};
GN Name=NEMF {ECO:0000313|Ensembl:ENSLACP00000018582.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018582.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018582.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; AFYH01060853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01060854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01060855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005995040.2; XM_005994978.2.
DR AlphaFoldDB; H3B9L1; -.
DR STRING; 7897.ENSLACP00000018582; -.
DR Ensembl; ENSLACT00000018715.1; ENSLACP00000018582.1; ENSLACG00000016363.1.
DR GeneID; 102354596; -.
DR KEGG; lcm:102354596; -.
DR CTD; 9147; -.
DR eggNOG; KOG2030; Eukaryota.
DR GeneTree; ENSGT00390000018516; -.
DR InParanoid; H3B9L1; -.
DR OMA; MFLEFFA; -.
DR OrthoDB; 129892at2759; -.
DR TreeFam; TF300515; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016363; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 565..675
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 1028..1120
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 449..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 329..373
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 520..547
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 453..467
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..746
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1028
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 128494 MW; B666F9D1CE29F34B CRC64;
MRCTVPRRKR LRGKSEESGA GEVEAVFGHA DKMKSRFNTV DIKAVLAELN DSLLGMRVYN
VYDVDNKTYL IRLQKPDTKA VLLIESGIRI HTTEFEWPKN LMPSGFAMKC RKHLKTRRLV
SVKQLGVDRI VDFQFGSDEA AYHLIVELYD RGNIVLTDHE YSILNILRFR TDESEDVKFA
VRERYPVENA KGPEPLISLE RLTEILSNAP KGEQLKRVLN PHLACGATLI EHCLIEVGFS
GSIKIDQHFD ITKDMEKVLL ALQKAEEFMC IADCFKGKGY IIQKQEKKPS LDPGKPPENL
LTYEEFHPFL FAQYAKCPYV EFESFDKAVD EFYSKLEGQK IDLKALQQEK QALKKLENVR
KDHIQRLETL HQAQEIDKVK GELIEINLQI VDRAIQVVRS ALANQIDWTE IGIIVKEAQA
QGDPVACAIK ELKLSTNHIT MLLKNPYVTS DEEEAKDDGD DDDGEEKEVE AAKAKGKKKK
EKNKQQQKLQ KNKPLLIDVD LSLSAYANAK RYYDHKRFAA KKEQKTVEAA EKAFKSAEKK
TKQTLKEVQT VTTIQKARKV YWFEKFLWFI SSENYLVIAG RDQQQNETIV KRYLRPGDIY
VHADLHGATS CVIKNATGEP IPPRTLTEAG TMALCYSAAW DARVITSAWW VCHHQVSKTA
PTGEYLTTGS FMIRGKKNFL PPSYLMMGFG FLFKVDEPYV WRHKGERKIK SQDEDLETVT
SITSELLSEE TETLEPGEEE DSSSDEEAGM TAPSQENQLK EAKTESNQSE ENLEEELEQL
EEHTGTSGEE SGEERNRKEN DTEGTEDMEK IKGEKGSEEV SYPDTTIDLS HLQAQRFIPV
HKTITDEESD NQCSSGKSLG RRHLSAKERR EMKKKKKQNE TEDSELVQQE NESKAQSSTN
KDIPKTVPAQ QLLKRGQKNK LKKIKEKYKD QDEEDRELMM QLLGSAGSSK EEKGKKSKKG
KLKEESSKKT QKLKVGQQAN TGAKKPGQKP LIDKGTLEIQ EVPHGNATIG EQEEKDQEEQ
EQEQQVNEES ENLLDSLTGQ PHPDDVLLFS IPVCAPYTTM TNYKYKVKLT PGTQKKGKAA
KTALHSFMFS KEATTREKDL FRSVKDTDLS RNLPGKVKVS APNLLAVKKK S
//
