ID H3BDC8_LATCH Unreviewed; 561 AA.
AC H3BDC8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=M-phase inducer phosphatase {ECO:0000256|RuleBase:RU368028};
DE EC=3.1.3.48 {ECO:0000256|RuleBase:RU368028};
GN Name=CDC25C {ECO:0000313|Ensembl:ENSLACP00000019899.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019899.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019899.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as a dosage-dependent inducer in mitotic control.
CC Tyrosine protein phosphatase required for progression of the cell
CC cycle. {ECO:0000256|RuleBase:RU368028}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490,
CC ECO:0000256|RuleBase:RU368028};
CC -!- SIMILARITY: Belongs to the MPI phosphatase family.
CC {ECO:0000256|ARBA:ARBA00011065, ECO:0000256|RuleBase:RU368028}.
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DR EMBL; AFYH01039565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01039566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BDC8; -.
DR STRING; 7897.ENSLACP00000019899; -.
DR Ensembl; ENSLACT00000020037.1; ENSLACP00000019899.1; ENSLACG00000017495.1.
DR eggNOG; KOG3772; Eukaryota.
DR GeneTree; ENSGT00940000161460; -.
DR HOGENOM; CLU_014464_4_0_1; -.
DR InParanoid; H3BDC8; -.
DR OMA; CEPRSYC; -.
DR TreeFam; TF101056; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:1902751; P:positive regulation of cell cycle G2/M phase transition; IEA:InterPro.
DR CDD; cd01530; Cdc25; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000751; MPI_Phosphatase.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR PANTHER; PTHR10828:SF64; M-PHASE INDUCER PHOSPHATASE 3; 1.
DR PANTHER; PTHR10828; M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25; 1.
DR Pfam; PF06617; M-inducer_phosp; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR00716; MPIPHPHTASE.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368028};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368028};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368028};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368028};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU368028};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 412..519
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
SQ SEQUENCE 561 AA; 64074 MW; B41A6B4FD0519D4C CRC64;
HTMSENPSCS SHVGLVPSFR SNCRTLLNLV RESQPSLSFS PEQPMSPVTS LTFNMNNLSA
FAGDTPRRCL DLSNVGQASV VLWPEEPEKW LSFSSGQPDS PHPLELNTPG HATVQLTLRT
KACPRRLKES YLPRFLCSSP KVKNLNPLEG RIYLGSPVCD KENVGTLLVL PICKPFFRHA
PQSSYLSKTA TNQLLPVSLS SQRCLNMESC AIRGVESPIT QDSLCLDEPI NECEELDGIT
EIFQQVETEV TSTSVIHSNI SMSSMAILLS GPLMSQDMEI SEVRNVSTNR GRLFRFPSMP
EKLNRPMLKR SVGLQGNETP VKTKRRKSIG SPIEEECENY VNHSRRSGLK RTLSLCNVDN
SNVSDEDVCH RQLIGDFSKV YALPTVTGQH QDLKYITGEM MAAMLCGEFL GLIEKYYIID
CRYPYEYDGG HIMGALNLYR QDDIFNFFLK DPIFPTSEHK RIILLFHCEF SSERGPKMCR
FLRGEDRNIN EYPSLYYPEL YVLKGGYKKF FHEFKEFCEP QAYCPMHHED FREKMLKFRS
KSKSWAGERR RREQITRLMK F
//
