ID H3BEF8_LATCH Unreviewed; 1413 AA.
AC H3BEF8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cytoplasmic linker associated protein 1 {ECO:0000313|Ensembl:ENSLACP00000020279.1};
GN Name=CLASP1 {ECO:0000313|Ensembl:ENSLACP00000020279.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020279.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR EMBL; AFYH01027028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01027037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000020279; -.
DR Ensembl; ENSLACT00000020419.1; ENSLACP00000020279.1; ENSLACG00000017825.1.
DR eggNOG; KOG2956; Eukaryota.
DR GeneTree; ENSGT00940000154817; -.
DR HOGENOM; CLU_005060_0_0_1; -.
DR InParanoid; H3BEF8; -.
DR OMA; CDHEISS; -.
DR TreeFam; TF101155; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017825; Expressed in mesonephros and 6 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF12348; CLASP_N; 2.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..169
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 105..143
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 256..492
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1166..1402
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 184..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1179..1210
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 191..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1413 AA; 156548 MW; 53DD092FD9976D2F CRC64;
FQLALLGMDI LSALVSRLQD RFKAQIGTVL PSLIDRLGDG KDQVRDQDQA LLLKIMEQAA
VPQYLWDRML GGFKHKNFRT REGVCLCLIA TLNVHGAQGL TLSKIVPHIC NLLGDPNFQV
RDAAINSLVE IYRHVGERVR ADLSKKGLPQ SRLNVIFGKF DEVQRSGNML LSSAVGEFKH
SDAVIEDPNR PPTATATSHK IKQPSTTSNL GLGLIRCWGS STFGSQCGAS KEGAGAVDEE
DFIRAFDDVP TVQIYSSREL EDSLNKIREA LSDDKHDWEQ RVTALKKIRS LVLAGAAEYE
GFFQQLRLLD GALKLSAKDL RSQVVREACI TFGYLSSVLG NRFDHGAETV MPTLLNLVPN
SAKVMATSGV AAIRLIIRFH THLKTLAPVL EFVFTDKKIK TCRRCYEFLD LMLQEWHTHS
LERHMSVLAE TIKKGIHDAD SEARLEARKC YWGFHGHFSR EAEHLYNGLE STYQKALQSH
LKNSDSIVSL PQSDRSSSSS QESLNRPLST KRSPTGSNVS REASTVSTKS AATPGSLQRS
RSDIDVNAAA SAKSKLSTPQ SSTPFSSAAA LPPGSYASLG RVRTRRQSSG SATGISTTPT
DTRGRSRAKV VSQSQPGSRS SSPGKLLGST YSGLSSGVQR VAAAPSSTEK RSKIPRSQGC
SRETSPNRLG LADRYGLGQP GRIPASVNAM RVISTSADLE AAVADALLLG DSRSKKSDLK
KTLQSFTLFC GEESNTYSPS IHSTVSHVTL NDGLCKFMKD KRRNIYINKA AQEGRRAERK
QKRLKPLNLN YHLVSGRVEL KRLCEIFTRM FADPHGKKVF SMFLETLVDF IIIHKDDLQD
WLFVLLTQLL KKMGADLLGS VQAKVQKALD VTRRWCPSAQ EFNILMRFIV DQTQTPNLKV
KVAILKYIES LARQMDPGDF INSSETRLAV SRIITWTTEP KSSDVRKAAQ VVLISLFELN
TPEFTMLLGA LPKTFQDGAT KLLHNHLKNS SNTSVICHPH TSCRNYGHRS SRASFNQEST
LSCRTRTDSR GPPPNGSMLD YDTENLNSEE IYSSLRGVTE AIQNFSFRSQ EDLNEPIKRE
GKKDCDGAPR DGGIASPASD IRGNMDVVEG GRTALDNKTS LLNTPPPRSF SGPRTREYNP
YNYSDTINAY DKTALKEAMF DDDVEQFRDA VSIDHSDLVA DLLKELSNHN ERVEERRAAL
LELLKITRED NLGVWDEHFK TILLLLLETL GDKDHSIRAL ALRVLREILR NQPARFKNYA
ELTIMKTLEA HKDSHKEVVR AAEEAASTLA SSIHPEQCIK VLCPIIQTAD YPINLAAIKM
QTKVIERISK ESLHQLLPDI IPGLLQGYDN TESSVRKASV FCLVAIYSVI GEELKPHLAQ
LTGSKMKLLN LYIKRAQTTN SNSSSSSDVS THS
//
