ID H3BL88_MOUSE Unreviewed; 1972 AA.
AC H3BL88;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=RIKEN cDNA 9930021J03 gene {ECO:0000313|Ensembl:ENSMUSP00000135696.2};
DE Flags: Fragment;
GN Name=Brd10 {ECO:0000313|Ensembl:ENSMUSP00000135696.2,
GN ECO:0000313|MGI:MGI:2444398};
GN Synonyms=9930021J03Rik {ECO:0000313|MGI:MGI:2444398};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135696.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135696.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135696.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000135696.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135696.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 10090.ENSMUSP00000135696; -.
DR PaxDb; 10090-ENSMUSP00000135696; -.
DR ProteomicsDB; 326971; -.
DR Antibodypedia; 955; 22 antibodies from 8 providers.
DR Ensembl; ENSMUST00000175726.8; ENSMUSP00000135696.2; ENSMUSG00000046138.16.
DR AGR; MGI:2444398; -.
DR MGI; MGI:2444398; Brd10.
DR VEuPathDB; HostDB:ENSMUSG00000046138; -.
DR eggNOG; ENOG502QQC8; Eukaryota.
DR GeneTree; ENSGT00390000011483; -.
DR HOGENOM; CLU_001633_0_0_1; -.
DR ChiTaRS; 9930021J03Rik; mouse.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000046138; Expressed in undifferentiated genital tubercle and 70 other cell types or tissues.
DR ExpressionAtlas; H3BL88; baseline and differential.
DR CDD; cd04369; Bromodomain; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR040214; KIAA2026.
DR PANTHER; PTHR31095; RIKEN CDNA 9930021J03 GENE; 1.
DR PANTHER; PTHR31095:SF3; RIKEN CDNA 9930021J03 GENE; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:H3BL88,
KW ECO:0007829|MaxQB:H3BL88};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 15..61
FT /note="Bromo"
FT /evidence="ECO:0000259|Pfam:PF00439"
FT REGION 732..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1817..1851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..162
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 732..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000135696.2"
SQ SEQUENCE 1972 AA; 213677 MW; 936387B02A4F02A5 CRC64;
XRGSRVPPQQ PSQGMCLLKM EEKFSSGQYR GITEFVADFR LMLETCYRLH GVDHWISKQG
QKLEMLLEQK LALLSRHLRE KTTIAVTSRG YYGLEEEKGT ACPSTRRRST PRSLAGLTSG
VFESIMVQVL RQEEQLRAKE EKRLREQERK EAEEACQKEV EEWERKLLAQ AAPACMENMW
EIPAIGHFLC LAQQILNLPE IVFYELERCL LMPQCNAFLS KIMTSLLSPP HRRPTLHRRP
TLPYRTWEAV LRQKVQQWYT AVGQTENPDN CAEKLGLCPQ FFKVLGEVNP LEERPFHELP
FYQKVWLLKG LCDFVYETQK EVQDAVLGQP IHECREVILG YDYLENAYVH FPQFCGADVR
IYKQRPFQAP EFPVPPIKVK RVPRIKLEKF KCDYANTSNG EHRCTKEGLP LAFKKEQEID
FDPACCPTKM NFDNHDITLE MEVKSNCDIK VHRPCEIEKT DCCKENLQKP RSPGEVTGFG
EPLSPGEIRF IENQEKYGEA SKIKTESNPL KENALKSCQI HINGSHIDHP DINCHKVVRD
ILLEHSLQSH KKLKLTKMRA KKKKKKKKKL KDVLNENLQR KREGLHSLPF KSYKPEIQNK
LLIIKKKGKH KKHKSGKKSI SKKAITKKRK TVTKSPAVPE FQLICTNLDE LRELITKIEN
ELKDLENSRK KSGKWYHRRQ AVKELHSTLI RLLNELLPWE PKLMKAFQRN RSRLKKDYDD
FRRQPDHGQF TRELWATDEC EGNPEREAPK AEVSKSVDAA EPLDTLEKEQ EGSDDMKLSE
IGFPMARSKL LKKELPSKDI VKTLPKTLKR QSKQSSYLDD STKELSPRKK AKLSTNETSV
ENLEVNMQIE CLKESKPPEL PTPESFASKA SVPVSTLQKG TKPIQALLAK NIGNKVTLTN
QLPPSTGRSV PAVEKPALSP EDTSPLKPAL TCLTSTKGPL QMVYKMPCGQ WLPVDLHSSS
VKIQMQPMVD SKTGEKIMQQ VLILPKNFVI QHKEGKAVEK EIAAPQQKGP EHCSPGPQTS
ASCSLVSVPV TSVSTQLPNT VLSKTSTPSS NVSARSQPLS PVASVSNALT SPVKTSQSEA
GKVKSTASST TLPQPHTSPT ISSTVQPLLP ATTLNESTDP GSSIPCFSQQ TVDSSEAKQE
LKTVCIRDSQ SILVRTRGGN TGVVKVQTNP EQNSPNSLSS SSVFTFTPQF QAFLVPKSTS
CSASSQVAGV TTTSSLPSFS QASTSVSISC GFHPPMGKNL KSTQGQTLSS GYVGPMIEKT
SYMPSSPLKP SVSSSSLLPS TTNSSVSVIS ISTGNFGQTN TNVIHTSTKP QQVDCITKSY
PVTRSEATTA VNGDVLGETP GQKLMLVSAP SGLPSGSVPS VNTAPEPTSA GVSTQKVVFI
NAPVPGGASS SAIVAESLRQ SLPSPLNKTY IKNPEQPQIV LIPSTVGAPI KINSSPTVSQ
IKDVKIGLNI GQAIINPPGN LPAMSSINIL QSVMPKGEDK SSKSCISPIS PNSNSAPASS
NIVNHSLPAA SESARTANTF SGIGASVPLS SLSVASSPAS AGTRPPVLVS GNDTSSRIMP
VLSNRLCPSN LGNTVAISTV KTGHLASSVL ISTTQPTVSP KCLTPALQIP VTVALPTPVT
TSPKIINTVP QSATIPGATR PVSLSKRQSQ TSLQFQSPGT TTIVPTNANT NKPPAELSPS
ASPGKIVNIS NVTSMPNQHM SPSLVKSTLG NNSIAGGSAI HTCSPPSNIT SLAGAPFSEP
CIQQKIVINT STPLAPGTQI MMNGARFIVP PQGLGAGSHV LLISTNPKYG PPLVLNSGQS
ILATPVDNPV QKIIQTSNSS LSGQPLKPSV RNSPKTVNSL GSPSSLSAVH TPPHIINTPA
KVCVPPAPPA ALTSVIKSSP ATLLAKTSLV SAISSSNPPL PSSTSVLHLD TSVKKLLVSP
EGAILNTINT AAAKVSSLPS PLPPVVSASQ NPASVFPAFP SSALEKPDTA AS
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