ID H3BNT0_HUMAN Unreviewed; 1100 AA.
AC H3BNT0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Calcium voltage-gated channel subunit alpha1 H {ECO:0000313|Ensembl:ENSP00000454990.1};
DE Flags: Fragment;
GN Name=CACNA1H {ECO:0000313|Ensembl:ENSP00000454990.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000454990.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000454990.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000454990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC120498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H3BNT0; -.
DR PeptideAtlas; H3BNT0; -.
DR ProteomicsDB; 41288; -.
DR Antibodypedia; 22964; 340 antibodies from 32 providers.
DR Ensembl; ENST00000569107.5; ENSP00000454990.1; ENSG00000196557.13.
DR UCSC; uc059ouy.1; human.
DR HGNC; HGNC:1395; CACNA1H.
DR VEuPathDB; HostDB:ENSG00000196557; -.
DR GeneTree; ENSGT00940000156666; -.
DR ChiTaRS; CACNA1H; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000196557; Expressed in lower esophagus muscularis layer and 98 other cell types or tissues.
DR ExpressionAtlas; H3BNT0; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:H3BNT0,
KW ECO:0007829|ProteomicsDB:H3BNT0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..307
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 364..617
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 630..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000454990.1"
SQ SEQUENCE 1100 AA; 121020 MW; 5F40D22C10B6D0EB CRC64;
XPYKPQWCRS REAWALYLFS PQNRFRVSCQ KVITHKMFDH VVLVFIFLNC VTIALERPDI
DPGSTERVFL SVSNYIFTAI FVAEMMVKVV ALGLLSGEHA YLQSSWNLLD GLLVLVSLVD
IVVAMASAGG AKILGVLRVL RLLRTLRPLR VISRAPGLKL VVETLISSLR PIGNIVLICC
AFFIIFGILG VQLFKGKFYY CEGPDTRNIS TKAQCRAAHY RWVRRKYNFD NLGQALMSLF
VLSSKDGWVN IMYDGLDAVG VDQQPVQNHN PWMLLYFISF LLIVSFFVLN MFVGVVVENF
HKCRQHQEAE EARRREEKRL RRLERRRRSK ALPVAVAVAE AQRRPYYADY SPTRRSIHSL
CTSHYLDLFI TFIICVNVIT MSMEHYNQPK SLDEALKYCN YVFTIVFVFE AALKLVAFGF
RRFFKDRWNQ LDLAIVLLSL MGITLEEIEM SAALPINPTI IRIMRVLRIA RVLKLLKMAT
GMRALLDTVV QALPQVGNLG LLFMLLFFIY AALGVELFGR LECSEDNPCE GLSRHATFSN
FGMAFLTLFR VSTGDNWNGI MKDTLRECSR EDKHCLSYLP ALSPVYFVTF VLVAQFVLVN
VVVAVLMKHL EESNKEARED AELDAEIELE MAQGPGSARR VDADRPPLPQ ESPGARDAPN
LVARKVSVSR MLSLPNDSYM FRPVVPASAP HPRPLQEVEM ETYGAGTPLG SVASVHSPPA
ESCASLQIPL AVSSPARSGE PLHALSPRGT ARSPSLSRLL CRQEAVHTDS LEGKIDSPRD
TLDPAEPGEK TPVRPVTQGG SLQSPPRSPR PASVRTRKHT FGQRCVSSRP AAPGGEEAEA
SDPADEEVSH ITSSACPWQP TAEPHGPEAS PVAGGERDLR RLYSVDAQGF LDKPGRADEQ
WRPSAELGSG EPGEAKAWGP EAEPALGARR KKKMSPPCIS VEPPAEDEGS ARPSAAEGGS
TTLRRRTPSC EATPHRDSLE PTEGSGAGGD PAAKGERWGQ ASCRAEHLTV PSFAFEPLDL
GVPSGDPFLD GSHSVTPESR ASSSGAIVPL EPPESEPPMP VGDPPEKRRG LYLTVPQCPL
EKPGSPSATP APGGGADDPV
//
