ID H3BP78_HUMAN Unreviewed; 1090 AA.
AC H3BP78;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=FA complementation group I {ECO:0000313|Ensembl:ENSP00000455189.1};
DE Flags: Fragment;
GN Name=FANCI {ECO:0000313|Ensembl:ENSP00000455189.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455189.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0007829|PubMed:16964243}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000455189.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3] {ECO:0007829|PubMed:17525332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [4] {ECO:0007829|PubMed:18691976}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [5] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8] {ECO:0000313|Ensembl:ENSP00000455189.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC124068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H3BP78; -.
DR MaxQB; H3BP78; -.
DR PeptideAtlas; H3BP78; -.
DR ProteomicsDB; 41412; -.
DR Antibodypedia; 15714; 156 antibodies from 25 providers.
DR Ensembl; ENST00000561894.1; ENSP00000455189.1; ENSG00000140525.20.
DR UCSC; uc059mzy.1; human.
DR HGNC; HGNC:25568; FANCI.
DR VEuPathDB; HostDB:ENSG00000140525; -.
DR GeneTree; ENSGT00390000005855; -.
DR HOGENOM; CLU_004843_1_0_1; -.
DR ChiTaRS; FANCI; human.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000140525; Expressed in ventricular zone and 137 other cell types or tissues.
DR ExpressionAtlas; H3BP78; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd11720; FANCI; 1.
DR InterPro; IPR026171; FANCI.
DR InterPro; IPR029310; FANCI_HD1.
DR InterPro; IPR029312; FANCI_HD2.
DR InterPro; IPR029308; FANCI_S1.
DR InterPro; IPR029315; FANCI_S2.
DR InterPro; IPR029313; FANCI_S3.
DR InterPro; IPR029314; FANCI_S4.
DR PANTHER; PTHR21818; BC025462 PROTEIN; 1.
DR PANTHER; PTHR21818:SF0; FANCONI ANEMIA GROUP I PROTEIN; 1.
DR Pfam; PF14679; FANCI_HD1; 1.
DR Pfam; PF14680; FANCI_HD2; 1.
DR Pfam; PF14675; FANCI_S1; 1.
DR Pfam; PF14676; FANCI_S2; 1.
DR Pfam; PF14677; FANCI_S3; 1.
DR Pfam; PF14678; FANCI_S4; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H3BP78,
KW ECO:0007829|MaxQB:H3BP78};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 2..107
FT /note="FANCI solenoid 1"
FT /evidence="ECO:0000259|Pfam:PF14675"
FT DOMAIN 111..197
FT /note="FANCI helical"
FT /evidence="ECO:0000259|Pfam:PF14679"
FT DOMAIN 205..368
FT /note="FANCI solenoid 2"
FT /evidence="ECO:0000259|Pfam:PF14676"
FT DOMAIN 382..612
FT /note="FANCI helical"
FT /evidence="ECO:0000259|Pfam:PF14680"
FT DOMAIN 632..799
FT /note="FANCI solenoid 3"
FT /evidence="ECO:0000259|Pfam:PF14677"
FT DOMAIN 812..1060
FT /note="FANCI solenoid 4"
FT /evidence="ECO:0000259|Pfam:PF14678"
FT REGION 1064..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000455189.1"
FT NON_TER 1090
FT /evidence="ECO:0000313|Ensembl:ENSP00000455189.1"
SQ SEQUENCE 1090 AA; 122947 MW; 6B5E7625A1504E58 CRC64;
XIQLTSMFKD VPLTAEEVEF VVEKALSMFS KMNLQEIPPL VYQLLVLSSK GSRKSVLEGI
IAFFSALDKQ HNEEQSGDEL LDVVTVPSGE LRHVEGTIIL HIVFAIKLDY ELGRELVKHL
KVGQQGDSNN NLSPFSIALL LSVTRIQRFQ DQVLDLLKTS VVKSFKDLQL LQGSKFLQNL
VPHRSYVSTM ILEVVKNSVH SWDHVTQGLV ELGFILMDSY GPKKVLDGKT IETSPSLSRM
PNQHACKLGA NILLETFKIH EMIRQEILEQ VLNRVVTRAS SPISHFLDLL SNIVMYAPLV
LQSCSSKVTE AFDYLSFLPL QTVQRLLKAV QPLLKVSMSM RDCLILVLRK AMFANQLDAR
KSAVAGFLLL LKNFKVLGSL SSSQCSQSLS VSQVHVDVHS HYNSVANETF CLEIMDSLRR
CLSQQADVRL MLYEGFYDVL RRNSQLANSV MQTLLSQLKQ FYEPKPDLLP PLKLEACILT
QGDKISLQEP LDYLLCCIQH CLAWYKNTVI PLQQGEEEEE EEEAFYEDLD DILESITNRM
IKSELEDFEL DKSADFSQST SIGIKNNICA FLVMGVCEVL IEYNFSISSF SKNRFEDILS
LFMCYKKLSD ILNEKAGKAK TKMANKTSDS LLSMKFVSSL LTALFRVLLW RYTSIPTSVE
ESGKKEKGKS ISLLCLEGLQ KIFSAVQQFY QPKIQQFLRA LDVTDKEGEE REDADVSVTQ
RTAFQIRQFQ RSLLNLLSSQ EEDFNSKEAL LLVTVLTSLS KLLEPSSPQF VQMLSWTSKI
CKENSREDAL FCKSLMNLLF SLHVSYKSPV ILLRDLSQDI HGHLGDIDQD VEVEKTNHFA
IVNLRTAAPT VCLLVLSQAE KVLEEVDWLI TKLKGQVSQE TLSEASSQAT LPNQPVEKAI
IMQLGTLLTF FHELVQTALP SGSCVDTLLK DLCKMYTTLT ALVRYYLQVC QSSGGIPKNM
EKLVKLSGSH LTPLCYSFIS YVQNKSKSLN YTGEKKEKPA AVATAMARVL RETKPIPNLI
FAIEQYEKFL IHLSKKSKVN LMQHMKLSTS RDFKIKGNIL DMVLREDGED ENEEGTASEH
GGQNKEPAKK
//
