ID H3BRL3_HUMAN Unreviewed; 300 AA.
AC H3BRL3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Ubiquitin family domain containing 1 {ECO:0000313|Ensembl:ENSP00000456292.1};
GN Name=UBFD1 {ECO:0000313|Ensembl:ENSP00000456292.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456292.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000456292.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0007829|PubMed:19690332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [3] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4] {ECO:0000313|Ensembl:ENSP00000456292.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC002400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BRL3; -.
DR SMR; H3BRL3; -.
DR IntAct; H3BRL3; 7.
DR EPD; H3BRL3; -.
DR MassIVE; H3BRL3; -.
DR MaxQB; H3BRL3; -.
DR PeptideAtlas; H3BRL3; -.
DR ProteomicsDB; 42100; -.
DR Antibodypedia; 55161; 162 antibodies from 22 providers.
DR Ensembl; ENST00000567212.5; ENSP00000456292.1; ENSG00000103353.16.
DR UCSC; uc059scn.1; human.
DR HGNC; HGNC:30565; UBFD1.
DR VEuPathDB; HostDB:ENSG00000103353; -.
DR GeneTree; ENSGT00390000012857; -.
DR HOGENOM; CLU_079085_1_0_1; -.
DR OMA; NKYDLKF; -.
DR ChiTaRS; UBFD1; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000103353; Expressed in secondary oocyte and 184 other cell types or tissues.
DR ExpressionAtlas; H3BRL3; baseline and differential.
DR CDD; cd17047; Ubl_UBFD1; 1.
DR InterPro; IPR039120; UBFD1.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR16470; UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1; 1.
DR PANTHER; PTHR16470:SF0; UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H3BRL3,
KW ECO:0007829|MaxQB:H3BRL3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 77..144
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 32640 MW; 4C8CACF5227BDD5F CRC64;
MEEPGMDTEA ETVATEAPAR PVNCLEAEAA AGAAAEDSGA ARGSLQPAPA QPPGDPAAQA
SVSNGEDAGG GAGRELVDLK IIWNKTKHDV KFPLDSTGSE LKQKIHSITG LPPAMQKVMY
KGLVPEDKTL REIKVTSGAK IMVVGSTIND VLAVNTPKDA AQQDAKAEEN KKEPLCRQKQ
HRKVLDKGKP EDVMPSVKGA QERLPTVPLS GMYNKSGGKV RLTFKLEQDQ LWIGTKERTE
KLPMGSIKNV VSEPIEGHED YHMMAFQLGP TEASYYWVYW VPTQYVDAIK DTVLGKWQYF
//
