ID H3BUT5_HUMAN Unreviewed; 93 AA.
AC H3BUT5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1 {ECO:0000256|ARBA:ARBA00021024};
DE AltName: Full=Transmembrane protein 188 {ECO:0000256|ARBA:ARBA00030458};
GN Name=CNEP1R1 {ECO:0000313|Ensembl:ENSP00000457787.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457787.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000457787.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000457787.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CNEP1R1 family.
CC {ECO:0000256|ARBA:ARBA00010998}.
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DR EMBL; AC007610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BUT5; -.
DR MassIVE; H3BUT5; -.
DR MaxQB; H3BUT5; -.
DR PaxDb; 9606-ENSP00000405635; -.
DR PeptideAtlas; H3BUT5; -.
DR ProteomicsDB; 43019; -.
DR Antibodypedia; 49431; 15 antibodies from 9 providers.
DR Ensembl; ENST00000565556.5; ENSP00000457787.1; ENSG00000205423.12.
DR UCSC; uc059tzo.1; human.
DR HGNC; HGNC:26759; CNEP1R1.
DR VEuPathDB; HostDB:ENSG00000205423; -.
DR eggNOG; KOG4606; Eukaryota.
DR GeneTree; ENSGT00390000008576; -.
DR OMA; DQTVCED; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000205423; Expressed in left ventricle myocardium and 188 other cell types or tissues.
DR ExpressionAtlas; H3BUT5; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0071595; C:Nem1-Spo7 phosphatase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IEA:InterPro.
DR InterPro; IPR019168; NEP1-R1.
DR PANTHER; PTHR20996:SF1; NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1; 1.
DR PANTHER; PTHR20996; UNCHARACTERIZED; 1.
DR Pfam; PF09771; Tmemb_18A; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:H3BUT5,
KW ECO:0007829|MaxQB:H3BUT5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 93 AA; 10421 MW; F0A04633E43F3323 CRC64;
MLLIVVSVCT ATGAWNWLID PETQKVSFFT SLWNHPFFTI SCITLIGLFF AGIHKRVVAP
SIIAARCRTV LAEYNMSCDD TGKLILKPRP HVQ
//
