ID H3C117_TETNG Unreviewed; 697 AA.
AC H3C117;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=DAB2 interacting protein b {ECO:0000313|Ensembl:ENSTNIP00000001933.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001933.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000001933.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3C117; -.
DR Ensembl; ENSTNIT00000001291.1; ENSTNIP00000001933.1; ENSTNIG00000013452.1.
DR GeneTree; ENSGT00940000155853; -.
DR HOGENOM; CLU_001727_1_1_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF12004; DAB2P_C; 2.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 1..189
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 322..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 580..625
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 324..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 76276 MW; 1751157BFB93CEA5 CRC64;
MACALVHILQ STGKAKDFLT DLMMSEVDRC GENEHLIFRE NTLATKAIEE YLKLVGQKYL
QDALGEFIRA LYESDENCEV DPSKCSSGDL QEHQGNLKMC CEVAFCKIIK SYCVFPRELK
EVFASWRQEC SSRGRPDISE RLISASLFLR FLCPAIMSPS LFNLTQEYPD DRTARTLTLI
AKVTQNLANF TKFGNKEEYM SFMNQLLEHE WSNMQGFLLE ISNPETISNT AGFEGYIDLG
RELSTLHSLL SEVVSQMDQS AASKLGPLPR ILREVNAALA NPSSVQMTAP GVSSEHVAPP
PVEAGCGISS GLQKMAIDND LAGRNSGIQP SPARSSSYSE TNEADLGMSN GSKSLSMVDL
QDPHHPEGGP DAIGEVSASV GGWSARVPQA AIPAGRRQGQ TPTEAAPGRP AQLLAPLSFQ
NPVYQMAACL PVSPRGMTDS GSECHSSVSS HSNNEDGPAG GKHAFLNHGG GGSGEEYTRR
SGEFTRRQLS LTEMQHQPAV PRQNSAGPQR RIDQPPPQSV TRGRTPPNLS GGPYPRPASG
NMMTSSPDWP GSGARLRQQS SSSKGDSPET KQRAHHKQEI AVLQEKLRAS VQKLEEYESR
LKGQDEQAQK VLMEYQARLE ESDDQQDDKD LQMKSIISRL MSVEEELKKD HSDMQAVVDS
KQKIIDAQSC RRSAIASLDA ANARLMSALA QLKERYS
//
