ID H3C521_TETNG Unreviewed; 1104 AA.
AC H3C521;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tumor protein p53 binding protein, 2a {ECO:0000313|Ensembl:ENSTNIP00000003340.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003340.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H3C521; -.
DR STRING; 99883.ENSTNIP00000003340; -.
DR Ensembl; ENSTNIT00000000256.1; ENSTNIP00000003340.1; ENSTNIG00000008659.1.
DR GeneTree; ENSGT00940000153463; -.
DR HOGENOM; CLU_008234_0_0_1; -.
DR InParanoid; H3C521; -.
DR OMA; ADCHLSE; -.
DR TreeFam; TF105545; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0043009; P:chordate embryonic development; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17225; RA_ASPP2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047163; ASPP1/2.
DR InterPro; IPR047166; ASPP2_RA.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR048945; RASSF8/10_RA.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR PANTHER; PTHR24131:SF8; APOPTOSIS-STIMULATING OF P53 PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF21712; ASPP1-2_RA; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00314; RA; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1104
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581432"
FT REPEAT 934..966
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 967..999
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1033..1095
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 97..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 397..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..497
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..852
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 122912 MW; F42A15131D48664E CRC64;
NGYTLTTLLS LARMFLTVYL SNNDQHFTEV PITPETLCRD VVELCKEPGE ADCHLSEMWR
GSERAVGEGE RMFDLLQRWG QHRPEVRFFL RHNRAPSREL AAGSRASEPK RNGLKGPPDR
RMENGVAPPR MDMTLAELQE MAARQQQQIE AQQQLLASKE QRLRYLKQQE QRQQQQASEQ
EKLQRLRENI DNQETRLKKV RALKGQVEQK RLSNGKLVEE IEQMNNLFQQ KQRELVMAAT
KVEELNRQLE LLKTSKMEHF NDNQSSVAEL DRLYKELQLR NKLNQDQNSK LQQQRENLNK
RNLEIVSMDK RISELRDRLW KKKAALQQKE NLPLPSEGQA GQHTGPSRVA AVGPYIQSST
MPRGPVRQDQ LVKPVYPDGT ATLPAHDPRS HPGPDWSSPG PESNTNGHGS ASTLPRMSSL
STANAEQGRQ HTHQTTLDDS KLKGDRKVRP FSMFEPTEVP TTSLRKNQSS DDLVRDAQSA
PKAPVKVPPP VPTKPKGPTI VPYGKTGLNT GTFPKAKPHN QQPQSAQGRS PLPPSQSQTL
PLPAKQDAPP AATVRPFTPE LPSSKDSSLN KPQTLAASSI YSMYTQQPGA AKPFQPGVQG
ALNRSQSRTN GFVSVYGKPV IPSGGSPHPE NPYLERRSPA PESEVDHSGA NGVAPNPPEA
PQPETERIPR PLSPTKLLPF ISNPYRHQSD GDLEALRKKL YNAPRPLKKR SSITEPEGPA
GPNIQKLLYQ KTTLAAMETT VTTPTTPTFA GEAEKAPETG QMLEPENHSH ISGATIPVLL
PIDQTKPPPV IPESEHIIPP PPPSHPAPRF DDALFPPPPP PGLDDLPNLP PPPPEGFLEE
FPPYPPPPYP SGAEQDSLGD DTFNMKAPEI TGQVTLPPGK RTNLRKPGSE RIDHSMRVKF
NPLALLLDSS LEGEFDLVQR IIYEVEDPSQ PNDEGITALH NAVCAGHTEI VKFLVQFGVN
VNAADSDGWT PLHCAASCNN VQVCKFLVES GAAVFAMTYS DMQTAADKCE EMEEGYTQCS
QFLYGVQEKM GIMNRGMVYA LWDYAGENPD ELAFHEGDCM TIVRREDEDE TDWWWARMGD
TEGYIPRNLL GLYPRIKPRQ RTLA
//
