ID H3CAA8_TETNG Unreviewed; 1107 AA.
AC H3CAA8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=PIGO {ECO:0000313|Ensembl:ENSTNIP00000005180.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005180.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000005180.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR AlphaFoldDB; H3CAA8; -.
DR STRING; 99883.ENSTNIP00000005180; -.
DR Ensembl; ENSTNIT00000005326.1; ENSTNIP00000005180.1; ENSTNIG00000002626.1.
DR GeneTree; ENSGT00910000144278; -.
DR HOGENOM; CLU_004298_2_0_1; -.
DR InParanoid; H3CAA8; -.
DR OMA; YPSFDIF; -.
DR TreeFam; TF354249; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1107 AA; 119170 MW; 920EA3B6F6722C96 CRC64;
SASRPGAAKL SLNESDRVRG TMKALPVLWP LLCVCALHSA GIYLFLSGFL LVRLEVNRTS
TCGDVLQPSG EEHGDFCRAQ PRFRRAVLLI IDALKMDFAR FDPNNTAPRP YENKLPVLEE
TLSGRPSHSR LYPFRADPPT TTMQRIKGFT TGSLPTFVDV GNNFASSAIL EDNLIHQFGQ
VGKRVVFMGD DTWESLFPRS FHRSLPFPSF NVKDLHTVDE GILRHLYPTM AGGDWEVLVA
HFLGVDHCGH RFGPDHPAMA DKLTQMDGVI RSVMERLQND TLLVVMGDHG MTDSGDHGGE
SQKETDAAIF LYSPSPLFPA PPSQGEPAVV PQTDLVPTLA LLLGVPIPYS SVGQVLLPLF
PSGQTEGLSQ LDALWINAKQ VNRFLETYAS MATDIPAHSL SELKEEFSRL SADYLAAVGG
APSSSPRLAA AMQAYLTRVR DTCRATWARF SPAKMAAGLL ILGLACVLCL AVSEKSGVLL
RGEGPGLKRP AAAALMAAGC VAAAQLLLRG HVEAAWCLAA AALDFELSFL WRCYRCGGVA
TTTKSACKPS RGGGWLRLPA PPAVVLLLRC CSLLSDSYVI AEGRAVTFLL FSLALYLPVR
LNWEGLLLPA GPEPLKAAGL LPSNAMPPPP SAVRRESGTF LGCWGLLTGC LFLSLSFHAC
REEQGACRPS PFLSPLSRLQ DHQLRNLHYA LAVLSLGSWT YLLRRWLRHY GNLNSSGGAV
FVARWLLPSA CACLALHWAV GATPEDSFRN LSELMRLAQL ALPRTAFALL GLALLLIWVD
PLTVFVKTRV AGSGAAPPPP RYRASTGVSP QAELHHLIPQ LYQRMRRSLD EGEPAGSGAA
GGRATVEAYG LGTVYSAPLL LLCGVLGVGL LLLHPEGMAL SFLLLLLEAG ALLHLHASSV
SLGGLQRAST GGFDVPWTPV ISWSLAAAQF FHATGHLPTF TSIQWSSAFV GFPDGHAGTA
LPAALVTLNT FASHILFGAA CPLLLLWPLL REAGGSAGGG RACGDEGQDA VMEMRLRENP
QFSSALLQLS ARYLFVQGVQ QVFSSVCAAA VLRRHLMVWK VFAPKLMFEA SSFLVSSAAL
LLGLTLVLRV DVAVGRWFRR LLPDASR
//
