ID H3CBL9_TETNG Unreviewed; 503 AA.
AC H3CBL9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Poly(U) binding splicing factor 60 {ECO:0000313|Ensembl:ENSTNIP00000005641.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005641.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000005641.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM half pint family.
CC {ECO:0000256|ARBA:ARBA00005987}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H3CBL9; -.
DR STRING; 99883.ENSTNIP00000005641; -.
DR Ensembl; ENSTNIT00000005789.1; ENSTNIP00000005641.1; ENSTNIG00000003069.1.
DR GeneTree; ENSGT00940000155594; -.
DR HOGENOM; CLU_020551_3_1_1; -.
DR InParanoid; H3CBL9; -.
DR OMA; HYYPLRE; -.
DR TreeFam; TF313987; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12370; RRM1_PUF60; 1.
DR CDD; cd12371; RRM2_PUF60; 1.
DR CDD; cd12648; RRM3_UHM_PUF60; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR006532; PUF60-like.
DR InterPro; IPR034209; PUF60_RRM1.
DR InterPro; IPR034211; PUF60_RRM2.
DR InterPro; IPR034212; PUF60_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR NCBIfam; TIGR01645; half-pint; 1.
DR PANTHER; PTHR47330:SF1; POLY(U)-BINDING-SPLICING FACTOR PUF60; 1.
DR PANTHER; PTHR47330; POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 3.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 92..170
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 189..267
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 348..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 53930 MW; B7C8BBF8B2A8E44C CRC64;
QGGPAVIMEN GQSTTTKLGL PPLTPNQQEA LQRAKKYAME QSIRSVLVKQ TLTQQQQFAS
LQMASLTVGF GDALSPLQSV AAQRQRALAI MCRVYVGSIY YELGEDTIRQ AFAPFGPIKS
IDMSFDSVTM KHKGFAFVEY EMPEAAQLAL EQMNSVVLGG RNIKVGRPSN IGQAQPIIDQ
LAEEARAFNR IYVASVHPDL SDEDIKSVFE AFGRIKSCVL AREPTTGRHK GYGFIEYDKA
QAAQDAVASM NLFDLGGQYL RVGKAVTPPV ALLTPAAPGG LPAAAAVAAA AASAKITAQE
AVGSSVLGAL AGPALLGLPQ AVMAAQAPGV ISGVTPARTG LPQVGLVNPV LATPPAAGES
KRKEEEEERQ RDGAVEPLSE QEQLSISGSS ARHMVMRKLL RKQESTVMVL RNMVGPGDID
DALEGEVTEE CGKFGRVKRV IVYQERQGEE DGAEVIVKIF VEFGEVAEMD RAIRALNQRW
FGGRQVVAEV YAQERFDSSD LSA
//
