ID H3CH57_TETNG Unreviewed; 804 AA.
AC H3CH57;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=RAS protein activator like 1 {ECO:0000313|Ensembl:ENSTNIP00000007585.1};
GN Name=RASAL1 {ECO:0000313|Ensembl:ENSTNIP00000007585.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007585.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007585.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CH57; -.
DR STRING; 99883.ENSTNIP00000007585; -.
DR Ensembl; ENSTNIT00000007745.1; ENSTNIP00000007585.1; ENSTNIG00000004920.1.
DR GeneTree; ENSGT00940000158715; -.
DR HOGENOM; CLU_008096_0_0_1; -.
DR InParanoid; H3CH57; -.
DR OMA; VTRAGVW; -.
DR TreeFam; TF105302; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd13369; PH_RASAL1; 1.
DR CDD; cd05135; RasGAP_RASAL; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037776; RASAL_RasGAP.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF3; RASGAP-ACTIVATING-LIKE PROTEIN 1; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..105
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 116..235
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 305..519
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 574..681
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 804 AA; 91571 MW; F5EEE0CB5D208AF1 CRC64;
MTKNTSLYFR IVEGRNLPAK GSSWCNPGKC LEQGCPCPVS RTATVWKTLN PFWGEEYTLH
LPMGFHSLSF HVMDEDTIGH DDVIGKITLA KDVIGSQAKG LDSWVNLTRV DPDEEVQGEI
HLCLELLKGA EKTSVRCKVI EARDLAPRDI SGTSDPFARF IFNNHSAETS IIKKTRFPHW
DETLELDLRP GGMGPSSVEV WDWDMVGKND LPGKENQVEI PFDCLHKTPH LESCFRLQPM
RSNEVDTSGN LGALRLKVRL IEDHILPSVY YQPLIHLLVE SVVAPAEVED SSALTMLEEV
TTVESRQDVA MTLVKIYLGQ RLVVPFLDYL NTREVQHTTD PNTLFRSNSL ASKAMEQFMK
ARLRHVGMPY LHEVLKPIIN RIFDERKYIE LDPCKITLNR SRRISFKGAV SEEEVRDSSV
EMLQDYLSSI TEAIVGSVSQ CPPVMRVTFK QLHKRVEERF TEPENEDVKY LAISGFFFLR
FFAPAILTPK LFQLREQHAD TRTSRTLLLL AKALQSVGNL GLQLGQGKEQ WMEPLHPIIR
LSVASVKEFL DRLIDIDHDI VSELPQRAVF LPSVTVKEGY LHKFKTEGPQ LLSRFAFKKR
YFWLTSETLT YAKSPDWQVR SSIPIQCVCA VERVDENAFQ QQNVMQLVTQ NNVGEVHIVY
IQCKNVNELN QWLSAIRKVS IYNERMLPSF HPGTHRSGKW SCCLQADRNV TGCSRTHSVT
LGDWSDPLDP DVETQTIYKQ LFQGRDKLRK KYLERAESNQ TTNTQEKIHP ADGAKGAVRL
SAAARLLAVM EDLERAHAAF QRTE
//
