ID H3CPP4_TETNG Unreviewed; 1385 AA.
AC H3CPP4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Rho guanine nucleotide exchange factor (GEF) 40 {ECO:0000313|Ensembl:ENSTNIP00000010227.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000010227.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000010227.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 99883.ENSTNIP00000010227; -.
DR Ensembl; ENSTNIT00000010408.1; ENSTNIP00000010227.1; ENSTNIG00000007421.1.
DR GeneTree; ENSGT00940000166741; -.
DR HOGENOM; CLU_001356_2_1_1; -.
DR InParanoid; H3CPP4; -.
DR OMA; LQQHACY; -.
DR TreeFam; TF334329; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 1071..1212
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 199..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 776..803
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 314..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 152419 MW; 7926067E07578E89 CRC64;
LAPEPVRYVC SSTTAALSSP GSATTANFSF FPQVFSVLES TYQHDTLRHL LDYFVPAKHL
LHKLQQPACS QYLGCLFLHS GWPLCLGEKV VVQLSTLDWR LLRSNDFYLQ VVPFSTRCPR
LALKCLAPGG RTVQEILVPE SQHPLVFTTE WLHSVNKERG HRRLDTCLVS TCDGVLRLPW
KEVVYPKFIH DPSEELSLMS SQDSSVPSRM SSEPDGLDSA PALPSRRRSE DGLGRTARNS
QVDGDYVELL EPRLGPDGGV DTQQRYLEMH GICKTKTLPL CRRGKAIKLR KGRAWGHGRL
ERSGSFRSVA GARREAGITK DDILRPQPLR EPNESARGRR SCSSSVQTSD DGDVSRKDSE
GLERPQLYFN GPVKERRPGV GKERDSNGLA PPCRDEHKCE DSEGGDNLAT ADTRDPINRR
ACHASEGHSD QGSHSDSVFE DADKPPSGGS DATTPTSDTT EKAKAEPLPV CNGQSGTSLL
DHSDEEATPG ETSGGQINGL VSKEPPLLRE LNPDLLQSGK FKLTGTVDRL GRALVITETK
VSEGSFCPEE MARVLACYHR ITRPAAKEKG LTVVMDSRGS SPSALLLSAL KLFQSGKSGE
MPFSPFLCSV SHGTRNGRPS AVRGQTAAAQ RDGRRLPALS LRLACLQTGR RDSSSALMGE
MTQSLESLTE RCKSALCLLG EALRSMDSEP VPDNIKAVPL SIDKHRQLMV SVLADQRITE
LQQRGGAWLA GLTNSNSGLA QKAALAATSE LYDGVDDALH KLVWLSNQKG RDLESLGRLA
ELVDKLDKEI ERVQSQLEEY REPPLSLSRL SLKQQKFKSF RETANIRVIF LGQISNLHSR
GWTLGCWSLW IFPSGAAQRD SVGTQRFGRL ERARLDRPER HPDPPSARQG EAAGHVPLLA
SLPPIPPSRF QDARSLALEL GGGALLDLWT QTVERYQRTV AHVKPRFLQS DRGQNQGQGE
ADWGLGAGGG DGGLQSWGSL ASLFRPQTCS TLKIGEDKGN KKTRLSPPAW LRPSLAVLIR
GVEVSSKEVV DHTGSPRQHV LLGRTEREMG ADRAGSTTQR FKLGLRQTFS KLYLLWCRML
SSERQYVAVL KGVEETYLPL LELSDTPASI RGKADALFPT WTSLSSFHSH NLLPAMEGAL
VQSLLQQDCF SKYRDQFLQY SHYIRTKPDL DSPLVTLAKP IKGGLESPLS FPHCLGAPVQ
RLEQYCEALE ELGGINPACD SALSILRHAQ RHGEDLRASD LILGCPIPVA ERGDLVRQGE
LTVCGGPRRK RAGVRNVFLY QHVLIFTKLK SPSPGRTVYS YKHSIRMGEM GLTQDVGEEG
VKFEVWVRHA ARTRDCITLQ AKDRDGKAAW THDVAHLLWT HAINNTELCL KESLCVGISS
KLLLD
//
