ID H3CX79_TETNG Unreviewed; 425 AA.
AC H3CX79;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Inositol polyphosphate-5-phosphatase Kb {ECO:0000313|Ensembl:ENSTNIP00000012864.1};
GN Name=INPP5K {ECO:0000313|Ensembl:ENSTNIP00000012864.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012864.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000012864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR AlphaFoldDB; H3CX79; -.
DR Ensembl; ENSTNIT00000013056.1; ENSTNIP00000012864.1; ENSTNIG00000009970.1.
DR GeneTree; ENSGT00940000156538; -.
DR HOGENOM; CLU_011711_3_2_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR CDD; cd09094; INPP5c_INPP5J-like; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF117; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF17751; SKICH; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 1..320
FT /note="Inositol polyphosphate-related phosphatase"
FT /evidence="ECO:0000259|SMART:SM00128"
SQ SEQUENCE 425 AA; 48943 MW; 63334E2C6BF1C929 CRC64;
VRLQIVTWNV ATAEPPEDIT SLLQLDVQPP TDLYVIGLQE VNAAPVRFLS DMLQEDSWSH
AFMDTLAPRG FVKVTSIRMQ GLLLLIFAKQ IHLPYIQKIQ ATYTRTGIFG YWGNKGGVSV
RFSFYGHMVC FLNCHLAAHM NYALQRVDEL EHILEVQDFD LTDTPRIRDH KVVFCFGDLN
FRITDHGLHF IRSSINSGRL NLLWSKDQLT MMKIKEPFLQ EFEEGHLNFK PTYKFDRNSE
NYDTSPSKSW FLLHGKKRKP AWTDRILWRI KPKTPPPAED GPDEYPLLVT QDKYTSDMSY
GVSDHKPVLG SFSLELRKCF DTPMLYISPV GVWSADEGAC LTYTVQEDFM SSTWDWVGLY
KVGFKSASDY ETFVWVRENE LPEVNEVIQI SIDRDEIPLL GGEYVLGYYS TNLQSIIGLS
TNFQV
//
