ID H3CXG3_TETNG Unreviewed; 907 AA.
AC H3CXG3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=WD repeat-containing protein 44 {ECO:0000256|ARBA:ARBA00021207};
GN Name=WDR44 {ECO:0000313|Ensembl:ENSTNIP00000012948.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012948.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000012948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CXG3; -.
DR Ensembl; ENSTNIT00000013140.1; ENSTNIP00000012948.1; ENSTNIG00000010052.1.
DR GeneTree; ENSGT00940000157557; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040324; WDR44/Dgr2.
DR PANTHER; PTHR14221; WD REPEAT DOMAIN 44; 1.
DR PANTHER; PTHR14221:SF0; WD REPEAT-CONTAINING PROTEIN 44; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 499..530
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 595..635
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 642..676
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 100158 MW; 11E44BAFA90C1E28 CRC64;
MASDTSDTEE FYDAPEDVNF APSPKVSSAK FVLPSAQNPV DNAQGASCEA ATSETQPDDS
LQIIDSIIEE SQKGGADEVA ELLDQLHVEV KAEVDDHVHQ GDDDAQEVPV ESAEPAVQPQ
LADQEQQEGI ARNGACAPPA DEPTEPPGPL DASQEAVQPP DLTSTVGQNQ PERAVVEQEL
RPADLLDQIS LTDRQVDLDA SGPLKPPRQF TVEPDIVAST KKPPPSRPPP PSGGPPPRPP
PPSWQNVPSK KSQESLRLSG LEGRKCQSPS DALEPSGLMS PCSTVRSLTK ELQHSLDLAS
ATSGDKVVTA QENEDEQPPS KSGQPTPGSQ RPRSNSGREL TDEEILASVM IKNLDTGEEI
PLIQAEEKLP AGINPLTLHI MRRTKEYITN DAAQSDDDDK SQPPLADTDG GKLKQKTTQF
KKFLGKSVKK AKHLAEEYGE KAVNKVKSVR DEVFHTDPDD PSSSDDEGMP YTRPAKFKAA
HSLKGPFDFD QIKVVQDLSG EHMGAVWTMK FSHCGRLLAT AGQDNMVRIW VLKTAFDYFN
NMRIKYNTEG RVSPSPSQES LCSSKSDDHG TSSVPEDPQT EDRNAPFRQV PFCKYKGHTA
DLLDLSWSKG FFTDLELSSL LSSSMDKTVR LWHISRRECL CCFQHIDFVT AIAFHPRDDR
YFLSGSLDGK LRLWNIPDKK VALWNEVDGQ TRLITAANFC QNGKYAVIGT YDGRCIFYDT
ERLKYHTQIH VRSTRGRNKV GRKITGIEPL PGENKILVTS NDSRIRLYDL RDLSLSMKYK
GYVNSSSQIK ASFSHDYSFI VSGSEDKYVY IWSTYHDLSK FTSVRRDRND FWEAIKAHNA
VVTSAVFAPH PSLIVPQETG AEKPEEECKS LDSTDSGALK TDHTEVLLSA DFTGAIKVFI
NRKNTVN
//
