ID H3CYW3_TETNG Unreviewed; 477 AA.
AC H3CYW3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DDB1- and CUL4-associated factor 10 {ECO:0000256|ARBA:ARBA00021765};
DE AltName: Full=WD repeat-containing protein 32 {ECO:0000256|ARBA:ARBA00030914};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013448.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013448.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000256|ARBA:ARBA00002614}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF10 family.
CC {ECO:0000256|ARBA:ARBA00005903}.
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DR AlphaFoldDB; H3CYW3; -.
DR STRING; 99883.ENSTNIP00000013448; -.
DR Ensembl; ENSTNIT00000013642.1; ENSTNIP00000013448.1; ENSTNIG00000010536.1.
DR GeneTree; ENSGT00390000012666; -.
DR HOGENOM; CLU_028919_2_0_1; -.
DR InParanoid; H3CYW3; -.
DR OMA; RFLDNRM; -.
DR TreeFam; TF323434; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR039085; DCA10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14588; DDB1- AND CUL4-ASSOCIATED FACTOR 10; 1.
DR PANTHER; PTHR14588:SF2; DDB1- AND CUL4-ASSOCIATED FACTOR 10; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 127..160
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..203
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 52711 MW; 85A3EAB9B1411C0F CRC64;
LGDGGGPAEP NATCPGEAET GSAPRSGSGG DLSADLRRGK SLFSWLQGRP TRRGVFVDPA
RDNFRTMTSL YCSMNSAVES VNLSTQTHGA VFNLEYSPDG SVLTVACEQT EVLLFDPISS
KHIKTLTEAH EDCVNNIRFL DNRLFATCSD DTTIALWDLR KLNSKVCSLH GHASWVKNIE
YDTNTRLLVT SGFDGNVITW DMNRFTEDGC PYKKFFHTRY LMRMRLTPDC SKMLISTSSG
YLLILHDLDL TQSLEVGSYR MLRARRTPLS SGIADGGTSA SRSAGTPRQG NDSSKTHPPR
EGRRSGLSPR NSLEVLTPEI PGERDRGNCI TSLQLHPKGW ATLIRCSSNT DDQEWTCVYE
FQEGAPTRLL VSPRCSLRLT HYIEEANVGR GYIKELCFSP DGRLICSPYG YGVRLLAFDQ
KCGELADCLP VQTSCLREIR SIYSHSDVVL TTKFSPTHCQ LASGCLSGRV ALYQPKF
//
