ID H3D004_TETNG Unreviewed; 437 AA.
AC H3D004;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=NAD(+) kinase {ECO:0000256|ARBA:ARBA00012120};
DE EC=2.7.1.23 {ECO:0000256|ARBA:ARBA00012120};
GN Name=NADK {ECO:0000313|Ensembl:ENSTNIP00000013840.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013840.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013840.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NAD kinase family.
CC {ECO:0000256|ARBA:ARBA00010995}.
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DR AlphaFoldDB; H3D004; -.
DR STRING; 99883.ENSTNIP00000013840; -.
DR Ensembl; ENSTNIT00000014035.1; ENSTNIP00000013840.1; ENSTNIG00000010910.1.
DR GeneTree; ENSGT00390000013792; -.
DR HOGENOM; CLU_008831_10_3_1; -.
DR InParanoid; H3D004; -.
DR OMA; ESAPYSC; -.
DR TreeFam; TF324076; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0003951; F:NAD+ kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019674; P:NAD metabolic process; IEA:InterPro.
DR GO; GO:0006741; P:NADP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00361; NAD_kinase; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR002504; NADK.
DR PANTHER; PTHR20275; NAD KINASE; 1.
DR PANTHER; PTHR20275:SF0; NAD KINASE; 1.
DR Pfam; PF01513; NAD_kinase; 1.
DR Pfam; PF20143; NAD_kinase_C; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 44..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 48097 MW; 4170A551EA22894F CRC64;
FLCQVCVMAG VKEVRVEAPP YCCSTCEGEE VACGNLARRR RKTRSLSTSS ASSSSSEYRR
TQSLHGPSPV TTFGPKACML QVPQAVMHIQ DPASQKLTWN TPPKSVLVIK KIQDASLLEP
FKELCIFLAK VKNMIVYVEK KVLEDPAISS NENFGAITKG FCTFREDLDN ISNLVDFIIC
LGGDGTLLYA SSLFESVPPV MAFHLGSLGF LTPFKFDTYQ SQVTQVIEGA PPLAARDRLK
VRVLKENREK KARVDELGAI WTNGDVEGSR RVAQYQQVLN EVVVDRGPSS YLSNVDLFLD
GHLITTVQGD GLIVSTPTGS TAYAVAAGAS MIHPNVPAIM IPPICPHSLS FRPIVVPAGV
ELKIMLSCDA RNTAWVSFDG RKRQEICHGD SITITTSCFP VPSICFRDPV NDWFESLAQC
LHWNVRKKQN YLSSEDE
//
