ID H3D1F6_TETNG Unreviewed; 483 AA.
AC H3D1F6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Muscarinic acetylcholine receptor {ECO:0000256|RuleBase:RU361191};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000014342.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000014342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC cellular responses, including inhibition of adenylate cyclase,
CC breakdown of phosphoinositides and modulation of potassium channels
CC through the action of G proteins. {ECO:0000256|RuleBase:RU361191}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361191};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361191}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191}; Multi-pass
CC membrane protein {ECO:0000256|RuleBase:RU361191}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Muscarinic acetylcholine receptor subfamily.
CC {ECO:0000256|RuleBase:RU361191}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361191}.
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DR AlphaFoldDB; H3D1F6; -.
DR STRING; 99883.ENSTNIP00000014342; -.
DR Ensembl; ENSTNIT00000014540.1; ENSTNIP00000014342.1; ENSTNIG00000011397.1.
DR GeneTree; ENSGT00940000158940; -.
DR InParanoid; H3D1F6; -.
DR OMA; TSERQNH; -.
DR TreeFam; TF320495; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071875; P:adrenergic receptor signaling pathway; IEA:UniProt.
DR GO; GO:0003161; P:cardiac conduction system development; IEA:Ensembl.
DR GO; GO:0010459; P:negative regulation of heart rate; IEA:Ensembl.
DR CDD; cd15297; 7tmA_mAChR_M2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001065; Musac_Ach_M2_rcpt.
DR InterPro; IPR000995; Musac_Ach_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF207; MUSCARINIC ACETYLCHOLINE RECEPTOR M2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR PRINTS; PR00539; MUSCRINICM2R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU361191};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361191};
KW Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Synapse {ECO:0000256|RuleBase:RU361191};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361191}.
FT TRANSMEM 32..57
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 69..95
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 149..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT DOMAIN 49..457
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 226..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..398
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 52417 MW; 6502B2451510D74D CRC64;
MDFLNFTSWN ASESNGTEVA EGGGSAYKTA EVVFIVLVAG SLSLVTVIGN ILVMLSIKVN
RNLQTVNNYF LFSLACADLI IGLCSMNLYT VYIVIGYWPL GPVVCDLWLA LDYVVSNASV
MNLLIISFDR YFCVTKPLSY PVKRTTKMAG MMIAAAWVLS FILWAPAILF WQFIVGGRTV
PERECYIQFF SNAAVTFGTA IAAFYLPVII MIQLYWQISR ASKSRVKKET RPSAANPEPP
LLPGRRGSGV PAADNNNLPG EELARSPGRS AADGEKLQNG KGPSSTGADG ETEGEDAREN
CTAAEEKESS NDSSSASAAN QKEEAPPAAA TTARPRASKL TCIKIKTASP GGGGGGYAPS
NTTVEIVPAA RQQQQVARKI AKVTKQPPKK KKKGAPSREK KVTRTIMAIL VAFVVTWTPY
NVMVLINTFC SACIPNTVWT IGYWLCYINS TVNPACYALC NATFKKTFKH LLLCQYKNIR
SAR
//
