ID H3D581_TETNG Unreviewed; 327 AA.
AC H3D581;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Mitochondrial fission regulator {ECO:0000256|RuleBase:RU369053};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000015670.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000015670.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in mitochondrial aerobic respiration. May
CC also regulate mitochondrial organization and fission.
CC {ECO:0000256|ARBA:ARBA00037378}.
CC -!- FUNCTION: Plays a role in mitochondrial aerobic respiration. Regulates
CC mitochondrial organization and fission.
CC {ECO:0000256|RuleBase:RU369053}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173,
CC ECO:0000256|RuleBase:RU369053}.
CC -!- SIMILARITY: Belongs to the MTFR1 family.
CC {ECO:0000256|ARBA:ARBA00005807, ECO:0000256|RuleBase:RU369053}.
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DR AlphaFoldDB; H3D581; -.
DR STRING; 99883.ENSTNIP00000015670; -.
DR Ensembl; ENSTNIT00000015877.1; ENSTNIP00000015670.1; ENSTNIG00000012695.1.
DR GeneTree; ENSGT00950000183215; -.
DR HOGENOM; CLU_059135_0_0_1; -.
DR InParanoid; H3D581; -.
DR OMA; CPRIHFQ; -.
DR TreeFam; TF331404; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0009060; P:aerobic respiration; IEA:UniProtKB-UniRule.
DR GO; GO:0000266; P:mitochondrial fission; IEA:UniProtKB-UniRule.
DR InterPro; IPR007972; Mtfr1.
DR PANTHER; PTHR14215:SF1; MITOCHONDRIAL FISSION REGULATOR 1; 1.
DR PANTHER; PTHR14215; PROTEIN OF UNKNOWN FUNCTION DUF729; 1.
DR Pfam; PF05308; Mito_fiss_reg; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|RuleBase:RU369053};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT REGION 166..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 134..161
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36201 MW; 14DDCB6946BC2F11 CRC64;
MSENHAPIEM DLAVTAAKSY GSSRSIVRRI ATSLPLKPCP RVHFQLYPYN EDANVLIGER
RKNGFVASLA DIAWLDRDEE DDEGYFVNPR SGMQAGFVFR AHQPHPQRKL LPRQRSLPSL
HQGARDPQAP SAANDEAIQK ISVLETELAK LRAQIAQIVL AQERATQPGT PEHLHRPPPP
SGSLPGPPPP PPPPPPPPLP GLQKSFSAIA LIKDRKAKRG DSQTVLDSKP AEMPNMLDVL
KDMSKVKLRS VRSHPADGET KGKSSEPADA AALIAEALRR KFAHRFRHDS EREGEDFKLP
TRDRKPQTET PAFGQHMLKQ TGKRKLV
//
