ID H3D932_TETNG Unreviewed; 1400 AA.
AC H3D932;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=CASK interacting protein 1 {ECO:0000313|Ensembl:ENSTNIP00000017023.1};
GN Name=CASKIN1 {ECO:0000313|Ensembl:ENSTNIP00000017023.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017023.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017023.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 99883.ENSTNIP00000017023; -.
DR Ensembl; ENSTNIT00000017238.1; ENSTNIP00000017023.1; ENSTNIG00000014015.1.
DR GeneTree; ENSGT00940000158025; -.
DR HOGENOM; CLU_003619_1_1_1; -.
DR InParanoid; H3D932; -.
DR OMA; LFCLHGQ; -.
DR TreeFam; TF320582; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12062; SH3_Caskin1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035495; Caskin1_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF11; CASKIN-1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 18..50
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 115..139
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 156..188
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 249..315
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 456..519
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 525..589
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 355..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1324
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 148102 MW; 7D025290736720B1 CRC64;
SELLGSAKKV NVNFQDTDGF SPLHHAALNG NLELITLLLE SQAAVDIRDQ KGMRPLHYAA
WQGKAPMKML LKSGSSVNGQ SDEGQIPLHL AAHGHYDVSE MLLQHQSNPC IVDNAGKTPL
DLACEFGRVG VVQLLLSSNM CAALLEPKKG DTTDPNGTSP LHLAAKNGHI DIIRLLIQAG
IDINRQTKAG TALHEAALCG KTDVVRLLLE SGINATVRNT YSQTALDIVY QFTATQASRE
IKQLLRDASA ALQVRALKDY CNNYDLTSLN IKAGDVITVL EQHPDGRWKG CIHDNRTGND
RVGYFPSTMV EVISKRSCRG TEASPHCSPT PSCGPHGGSN EEIWVLRKPV FAGGDRSSLG
SSSSVNSVRS SGSGQSAGSA PHILHAQAEG VKLLATVLSQ SAKAKEHLLE QTKSMDQPAG
SNSSSRTSSQ SGCPLHEAPP YEATAARKGE GPGEGKSSEA VVQWLSDFQL QVYAPNFLGA
GYDLPTISRM TPEDLTAIGI TKPGHRKKLT SEINKVSVSE WLPEHKPANL GEWLSAIGLS
QYHQVLVQNG YENIEFITDI TWEDLQEIGI TKLGHQKKLM LAVKRLAEMQ RSSEGRSSFK
KKPPPITQQQ EVMSMDSPPP DVVPSFSAEV MSPKMSTFQD SELSSELQNA MSQPGHEISK
AQRARSFSKD HDEAMTGGGG PPKKEARTMR QQSSQGSSSS SRGSVSSQGK RHSHSHSQPA
PPYTPPHTPT KTRTSSSSST SSAQSIASPQ SKPKPAHFGQ GERPQSPRSH SNQSPTHRGA
LCVTEVKDNQ QSQVPLLCLP PEGEMPEGDG AESSALQKKR AHSLNRYAVS DGEGDEPVGG
GRNGGKAPAA GGQGSAASKA EGEKYATVTH RVSRSHSVRN QDKSASRNQT QSFALRQKKK
GPPPPPPKRS SSAISSSNSN LADANAQPQT HATAGGLLDV PYHQQRRASD LGVSVETAPV
ETNSAGSVRS IAAMLEMSSI GGGAKGMALQ KNFLQMPDRA FSPATQVGKT REAIGLDGEV
VNRRRTISGP VTELVEAASS GGSGSSSENL PFAEEGSLTI RRQGRGEGQG DGDGPQADGG
YAQEDVSRPE ANPTLKRRPR STKSQPNGAD FTLQESSTVK RRPKSRDKEP DGFAELAAAN
TQPAAFQNGT ATVKRRPTSD ASVTDQSPPQ AAAARRRNSV EQAAPGSTDG GPARKPKPPV
SPKPIVAQIK RQGGPQTPPH PASNKSIPLP GPGTPGSPVE GKKIPPPVSP KPAPPPTAPK
PAKLVHSMTS SSSPPGLPPT NIPSPPNAKP LSPSPQSPHT PQTPPTPQTP ATPSPTPPPV
KPPRSSIGGV SVDSGTPGDF LVQQKLEETS ASLAAALQAV EDKILHQEDS VAEQKTTVSI
LDDIGSMFDD LADQLDAMLE
//
