ID H3D9J5_TETNG Unreviewed; 1869 AA.
AC H3D9J5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Calcium channel, voltage-dependent, L type, alpha 1F subunit {ECO:0000313|Ensembl:ENSTNIP00000017186.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017186.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 99883.ENSTNIP00000017186; -.
DR Ensembl; ENSTNIT00000017402.1; ENSTNIP00000017186.1; ENSTNIG00000014174.1.
DR GeneTree; ENSGT00940000159855; -.
DR HOGENOM; CLU_000540_0_1_1; -.
DR InParanoid; H3D9J5; -.
DR OMA; VCTLNQT; -.
DR TreeFam; TF312805; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 66..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..979
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1178..1201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1335..1369
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 247..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1621..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1415..1432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 159
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 498
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 880
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1869 AA; 212063 MW; 5A86C070F89E6AE6 CRC64;
LFSVVLETMT HKSGEQATTH HVPGKPGGLD VKALRAFRVL RPLRLVSGVP SLQIVLNSIM
KAMVPLLHIA LLVLFVIIIY AIIGLELFIG RMHKTCYYTT TDNYVEDDPV PCAFAGHGRQ
CVVNGSECRG RWDGPNGGIT NFDNFFFAML TVFQCITMEG WTDVLYWMND AIGFELPWVY
FVSLVIFGSF FVLNLVLGVL SGEFSKEREK AKARGDFQKL REKQQMEEDL CGYMDWITQA
EDMDDLDEDG NPHKKKASLP ASETASENTV NIDEEHTNCC QACWDCQVLP VSRYSRTLRR
WNRVCRRNCR TAVKSTTFYW VVLLLVFLNT SLSASEHYNQ PLWLTQVQDI ANKVLLSLFT
VEMLLKMYSL GLAHYFVAFF NRFDCFVVCG GIVETILVEM EIMPPLGISV LRCVRLLRIF
RVTRHWTALS GLVASLLNSM KSIASLLLLL FLFLIIFALL GMQLFGGKFN FDETQTKRST
FDSFPQALLT CFQILTGEDW NVMYDGIMAY GGPVFSMIVC VYFVILFICA DFSQRATHTL
KNRLLRQWRQ TTRRGEKQQK QKKNNGRIKG RKTPEKAGAE GGRLTRPFFL GSQVDMDEDT
EYEEEEEELH EGERRLLDGG VQLKMADLAP PKEKVLPIPE GSAFFCLSKT NPVRVACHTL
IHHHIFTNLI LVFIILSSCS LAAEDPIRAH SFRNTILGYA DYAFTSIFTV EILLKMTVHG
AFLHQGSFCR NWFNLLDLLV VSVSLVSFFL HSSAISVVKI LRVLRVLRPL RAINRAKGLK
HVVQCVFVAI RTIGNIMIVT TLLQFMFACI GVQLFKGKFY RCTDEAKHTP EQCNRGTFVV
YKDGDVSHPM VRERIWHNSD FNFDNVLMGM MALFTVSTFE GWPALLYKAI DANGENSGPI
YNYRVTFREQ GEQEYKNCEL DKNQRQCVEY ALKAQPLKLY IPKNPVQYKF WAIINSTGFE
YVMFVLILLN TVTLAIQHYE QSKTFSHVMD ILNMVFTGLF TVEMLLKLLA LRPRHYFVDA
WNSFDALIVV GSVVDIVVTE FSSGEDSSRV SITFFRLFRV MRLVKLLSKG EGIRTLLWTF
IKSLQALPYV ALLIAMIFFI YAVIGMQTFG KIAMQDYTQI NRNNNFQTFP QAVLLLFRCA
TGEAWQEIML ASLPGKRCDP ESDYEPGEEF SCGSNFAIVY FISFFMLCAF LIINLFVAVI
MDNFDYLTRD WSILGPHRLD EFKRIWSEYD PEAKGRIKHL DVVALLRRIQ PPLGFGKLCP
HRVACKRLVA MNMPLNSDGM VTFNATLFAL VRTALKIKTE GIPEQENEEL RAIIKKIWKR
MKPKLLDEVI PPHKEEEVTV GKFYATFLIQ DYFRKFRKRK EKGNFAGETD DTNPSAVRKA
GLKTLQDLGP EMRLALNEDQ RLQGDSENDF GPEKDRQGST LTTPTNDIFS SGSGGLLGDG
PPSNGAAVHR VATLTKMPNG SDHEDHFRHD NKRTSLNHHH SRRPSGRNGA LDYSHQRASY
YKHGRRDSRD RYWRKGDVEA YGDQSCYSRE EDNDSIASRD RYLTSDLLSS PQTRQLGADV
AQSPFQHGTS CFSHRQSFSK SQIFIHQDLN PVTFLGNSIH YPDEPPLYRD QYEGLPYSHS
SYSNGYSEGR RTTRRRLLPA TPTGRKPSFN IQCLRRQGSS DDLPMPGTYH PTSPPRRARP
QMVNSYDSRH SAAHSAAPSS TPWANPCPRR GRLLYAPLIL VEEEETVRLT VSSPLQALAS
QQQHPDQPAP PPYRAYTTLR VPSQLGAQLT DKRGSADSLV EAVLISEGLG LYARDPKFVA
FAKREIADAC HMTVDEMESA ANDLLSSGSH GLLANAAADP AGLYSDEEPI RTGRDEDELA
DEMSCVTSF
//
