ID H3D9U9_TETNG Unreviewed; 1417 AA.
AC H3D9U9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=GTPase activating protein and VPS9 domains 1 {ECO:0000313|Ensembl:ENSTNIP00000017290.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017290.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017290.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR Ensembl; ENSTNIT00000017508.1; ENSTNIP00000017290.1; ENSTNIG00000014276.1.
DR GeneTree; ENSGT00940000156611; -.
DR HOGENOM; CLU_002165_1_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 144..352
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1277..1417
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 447..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1417 AA; 157691 MW; 0A62441EFE35868E CRC64;
MVKPDIHTLA HHLKQERLYV ASEKQLIQRL NNDVLKTAEK LYQAAWIAKQ QRINLDRLIL
TSAEASPAEC CQHAKGLEDT QFVDGYKSLG FQEMIYGEFL ARLRENPRLV ASCLVAGERL
NQEHTQAVIH TVFTSLYGNC IMQEDESFLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
LFKLFSEGLY SAKVFLTATL HEPIMQLLVE DEDHLETDPA KVLERLTPTQ QEQFGEKGSE
SYKLRVQSAV DANEAKLVAL VNKFIGYLKQ NTYCFPHSLR WIVSQMYKTL SCVQRFEVGE
VRTMCTDLLL TCFICPAIVN PEQYGIISDA PINEVARFNL MQVGQLLQQL AMADDADPRR
KSSLSKFDKS CVAAFLDVVI GGRAVETPPM SSMNLLEGLN RTAVYMTHNQ LFVLVDFVRS
MAGDHLREEE HMALETLLAN VPQNQTVKSN SLEPTPSNTH QLSPATTPAN KKNRLPIASR
SRSRSNISQE GELDGNSQES LQELMPEEVL VISLGVSPQS VPGMMSENEV LNLQMSDGAQ
GDGHTDDTKL HGKPDKTLRF SLCSDNLEGI SEGPSNRSNS VSSLDLEGES VSELGAGPSG
SNGVEALQLL EHEQATTQDN LDDKLRKFEI RDMMGLTDDR DISETVSETW STDVLGSDFD
PNMDEDRLQE IAASGAAAEN MLGTLLCVGP GSVLLDPYGS TISETTSEAW SVEVLPSDSE
TPDLKQEERL QELGKSCSGV GSTSDDTECP RGLASRPSTP GLSVVSGISA TSEDIPNKIE
DLRSECSSDF GGKDSVTSPD GEESVHGAHH LTSPPSQVDS LLAMFDPLTC GSSTGTIVRP
KVHYARPTHP PPDPPIETSM LGGQDIRHSL YMPHCLTQAD LEHNKQRYSF PDRLVRSRSS
DIVCPGRRPT SDPCLNRRAA VEEREPAGAF ALGPTSSPSK DSLKGEVEDR KDSDDEKSDR
NRPWWKKRFV SAIPKEDSLL TQSSQVQAAE DILDKYRNIK RTSPSNGATG GTSYDGTGDL
CGEDAVPDSM QNISTDDLPD SASQTAQQHD SKFSFSDAKK KLRLALCSAD SVALPIMTPA
TTRNGLPDHM ESEDNEIVCF LKVQLAEAIN LQDKNQMAQI QETTRCVSRF DARICRKLLA
VIAEDYRKRA PYIAYLTRCR QGLQTAQAHL ERLLQRVLKD KEVANRYFTT VCVRLLLEHM
ESKMLDFIKA FQGCTAADDK TAAMEDFLRY LYGAMASDAI WQYASEEQLQ DAQMAIERSV
MNRIFKLAFY PNQDGDSLRD QLFHEHIQRL SKVVTANHKA LQIPEVYLKE APWPSAQSEI
RTINAYKTPR DKVQCILRMC STIMNLLSLA NEDSVPGADD FVPVLVFVLI RANPPCLLST
VQYINNFYAG RLSGEESYWW MQFTAALEFI KTIDDRK
//
