ID H3DDC6_TETNG Unreviewed; 503 AA.
AC H3DDC6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=C3 and PZP like alpha-2-macroglobulin domain containing 8 {ECO:0000313|Ensembl:ENSTNIP00000018519.1};
GN Name=CPAMD8 {ECO:0000313|Ensembl:ENSTNIP00000018519.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018519.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000018519.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3DDC6; -.
DR Ensembl; ENSTNIT00000018745.1; ENSTNIP00000018519.1; ENSTNIG00000015449.1.
DR GeneTree; ENSGT00940000162399; -.
DR HOGENOM; CLU_542448_0_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR PANTHER; PTHR11412:SF139; C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..503
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003582219"
FT DOMAIN 34..105
FT /note="Complement C3/4/5 macroglobulin"
FT /evidence="ECO:0000259|Pfam:PF17790"
FT DOMAIN 131..222
FT /note="Macroglobulin"
FT /evidence="ECO:0000259|Pfam:PF01835"
FT DOMAIN 224..303
FT /note="Macroglobulin"
FT /evidence="ECO:0000259|Pfam:PF17791"
FT DOMAIN 351..410
FT /note="Macroglobulin"
FT /evidence="ECO:0000259|Pfam:PF17789"
SQ SEQUENCE 503 AA; 56944 MW; C518DA2FD8DEE721 CRC64;
CNGLLRWRLC SLLICLIYTK QGAEWVQKPQ NQRGYLVAAP SVFRAGVEES VSVTIFGATA
ETRVQAQLSV KGQTVAHSHD SVLDKGTIKL QVPSGLRGQA HLKVWGNRHS EGGYIFHNYT
TVTVESKGTA VFIQTDKPIY KPQHRVLINV YTVTPDLRPV NDKIEAYVLD PRGSRMVQWK
GLKPICCGVV NMSFPLSDQP VFGEWFVFVE VQGYTYNRSF EVQKYVMPKF ELVIEPPPYI
RDLNSCQQAS VRARYTFGKP VVGKLTVNMT VNGVGYYRQE TGHPVIKTME IKGSANFSLC
VKDMMPPDPD HFRGSVSIWA SVTSVDGSRQ TTFDDSTPVH KQLIDIKYSK DTRKQFKPGL
PYKGKIEVTY PDGSPANGVK VRVKAELTTK DNVYTSELIS KDGEATFEIP SIPTAAQYVW
LEIFKELADF DVSDAFGIPK DDGHFWWPGL SLRRRRRSSV FPWHWDITKD ARFAFTSNSG
NRADRDDRHG EFEPPAEWRH VHR
//
