ID H3DER8_TETNG Unreviewed; 1153 AA.
AC H3DER8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019011.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR AlphaFoldDB; H3DER8; -.
DR Ensembl; ENSTNIT00000019239.1; ENSTNIP00000019011.1; ENSTNIG00000015925.1.
DR GeneTree; ENSGT00550000074985; -.
DR HOGENOM; CLU_001832_0_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 263..430
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 449..711
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..567
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 129211 MW; 7A3C678B16C5E49D CRC64;
MGKLRRKHNW KGRQQNDSQK PADDNRTDVV VELQDGSKLK GVDKSNALVL PANKSKKKTT
SLSRVSTKKP LTKRQRRELQ KVLERKEKKA QRADILSKLA DVQLPESERK LLYTTSKLGT
GEKLYNAQQI LDGGKDGDLG TKISSVSGAH RKRKWKEEED EEEIEDESND PDTSSDEAED
DDGMAGKDEC TDASTSSQDS KQEVIEEERC EKEEEDEKKT SGEDKTQSKK PSQPAIFVPV
DRSPEIQEAR LKLPVLSEEQ VIMEAVRENP CTVICGETGS GKTTQVPQFL YEAGYATDSG
IIGITEPRRV AAVSMSHRVA KEMNLPTRVV SYQIRYEGNV TDETKIKFMT DGVLLKEIQK
DFLLKRYSAI IVDEAHERSV YTDILVGLLS RIVPLRNKKG MPMKLLIMSA TLRVEDFTDN
PKLFSTPPPV IKVDARQFPV SIHFNKRTPL EDYTGEVFHK TCKIHRMLPS GGILVFLTGQ
AEVHSLCRRL RRAFPFRKEH TNTGEPEEFD SSEALRKFKK AKQKKTISLP RIDLDNYSAL
PVDEGDEDRE AGIGDEEDEG SDLDIGDDPT SAEEKADPSI PLYVLPLYSL LAPEKQAMVF
RPPPPGTRLC VVATNVAETS LTIPGIKYVV DCGRVKKRYY DKVTGVSSFK VTWISQASAN
QRAGRAGRTE PGHCYSRLYS SAVFADFSLF SEAEITRRPV DDLVLQMKDL NIDKVVNFPF
PTPPSAEALV AAEQLLISLG ALKEPPQASR VKEMERARLS CPISPLGAMA SFPVAPRYAK
MLALGKQQDC LPYVIAVVAA MTVRELFEEL NRPAGSNDES ATLTQRRARL TQMRRVWAGQ
GESLLLGDLM VMLDTGAVGA CEFAGCSLKF CEDNGLRYKA MVEIRRLRGQ LTNAVNAVCP
EMGTFVNPKM PPPTEQQVVC LRQIVLAGLG DHLARRVQAE DLLDPKWKNG YKTPLMDEPV
FIHPTSALFK TLPEFVVYQE IMETSKMYMK GVSAVEAEWI PRLLPQYCHF GATLEAPSPW
LCSSSGTVRC HRSSTFFRVG WQLPAVEMEY PEGLDRYKLF SRFLLEGQVS PNLKKYVPHL
LSSPSVMLKT WAKLQPRTEA LLGALVSKRV DSREALLSVW KTEDKYLLSA YCQWLPEALH
QQVAKSWPPK TEQ
//
