ID H3DGV7_TETNG Unreviewed; 1225 AA.
AC H3DGV7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019751.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019751.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H3DGV7; -.
DR STRING; 99883.ENSTNIP00000019751; -.
DR Ensembl; ENSTNIT00000019981.1; ENSTNIP00000019751.1; ENSTNIG00000016644.1.
DR GeneTree; ENSGT00940000166212; -.
DR HOGENOM; CLU_004732_0_0_1; -.
DR InParanoid; H3DGV7; -.
DR OMA; MAIGPCI; -.
DR TreeFam; TF351835; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF448; PROTEIN JAGGED-1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 16.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1225
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581964"
FT TRANSMEM 1069..1093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..228
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 229..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 411..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 449..484
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 486..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 524..560
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 590..626
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 628..664
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 666..702
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 704..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 743..779
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 781..817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 819..855
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1153..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 186..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 199..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 219..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 252..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 361..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 437..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 453..463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 474..483
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 512..521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 550..559
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 616..625
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 769..778
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 807..816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 845..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1225 AA; 133919 MW; EBD6954C43CC2D37 CRC64;
QQQSGGMVSR RGSLVAALLL CLLAQVSEGS GQFELQILSM HNVNGELLSG VCCDGARSAG
DRKCARDECA TFFKVCLKEY QSRVHAAGPC SYGMGSTPVL GGNTFSLKSS VRIDKSRITL
PFSFAWPRSY TLIVEAFDSN NETSGADSRL IEKAPHSGMI NPSPQWQKLT HNGPVAQFEY
QIRVICDEHY YGFGCNKFCR PRDEFFGHYT CDYNGNKTCL EGWSGPDCNT AICRQGCSIE
HGSCKEPGEC NCLYGWQGQY CDKCIPHPGC VHGTCVEPWQ CLCDTNWGGH LCEKDLNYCG
THQPCLNGGT CINTGPDKYQ CTCAEGYSGA NCERAEHACL SGPCSNGGSC SETSQGYECQ
CAAGWSGPSC TIDIDDCAPN PCNHGGTCQD LVNGYKCHCP PQWMGKTCLI DANECDSKPC
VNANSCRNLI GGYFCECVPG WTGQNCDIDI NDCRDQCQNG GTCKDLVNGY RCMCPAGFSG
EHCEKDVDEC LSSPCLNGGR CQDEVNGFQC LCLAGFSGNL CQLDIDYCSP NPCLNGASCF
NLATDYYCAC PEDYEGKNCS HLKDHCRTTT CKVIDSCTVA VASNSTPGGE RYISSNVCGP
HGRCRSQAGG QFTCECQEGF RGTYCHENIN DCESNPCHNG GTCIDKVSVY QCICADGWEG
DHCQLNIDDC STSPCYNGGT CRDLVTDFFC ECKNGWKGKT CHSRESQCDE ATCNNGGTCY
DEGDAFQCKC SPGWEGTTCN IAKNSSCLPN PCENGGTCVV AGESFTCVCK EGWEGPTCTQ
NTNDCSPHPC YNSGTCVDGE NWYRCECAPG FAGPDCRINI NECQSSPCAL GSTCVDEING
YRCLCPPDRT GSHCHEVMRK PCFVNGHITP DGVKWDEDCN TCHCANGKVV CTKMWCGPTS
CRVSANGRRE CPSGQTCVPI RENQCFVKPC PGFGECSNYL PPPSKCHPGS CFQDNSCANI
TFTFNKETIS EASLTVEDVC KQLRRLYVVK NFSLEHSTSI NCDPSFSASN EIHVCISTED
HQLDRSPIKE ITDRIIDLLS KGNVNNTILT AIAEVRVPKP DKPVSSSDYL VPLLSSIFIG
LWVLVLVFSL LWCMRRRRKQ SNHNGASATG SEDNTTNNVR EQLNQIKNPI EKHVGLTVAI
KDYENKNSII AKIRTNHPEG DEDNKERHLQ KGRFAKQPTY TLVERDEKTP ISNPNSTSKN
PNWTNKQDNR DLETANSINR MDYIV
//
