ID H3DL95_TETNG Unreviewed; 883 AA.
AC H3DL95;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=FCH and mu domain containing endocytic adaptor 1 {ECO:0000313|Ensembl:ENSTNIP00000021293.1};
GN Name=FCHO1 {ECO:0000313|Ensembl:ENSTNIP00000021293.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021293.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021293.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR AlphaFoldDB; H3DL95; -.
DR STRING; 99883.ENSTNIP00000021293; -.
DR Ensembl; ENSTNIT00000021528.1; ENSTNIP00000021293.1; ENSTNIG00000018127.1.
DR GeneTree; ENSGT00940000160489; -.
DR InParanoid; H3DL95; -.
DR OMA; TDSAVMD; -.
DR TreeFam; TF328986; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF6; F-BAR DOMAIN ONLY PROTEIN 1; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 3..250
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 623..882
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 471..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..556
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 97439 MW; 215856B7D6E4C60D CRC64;
LKMAFFQNNF WGEKNAGFDV LYHNMKHGQL ATKELAEYIR ERAAVEETYS KSMSKLAKMA
SNSSPQGTFA PMWDVFRVSS DKLALCHLEL MRKMNDLIRD INKYGEEQVK IHRKTKEEMV
GTVEAVQALQ VQSAHLQKSK EVYHAKCLEL DRLRKEGAPL KELEKAELKS KKAAESFASC
IEKHNRVGAD FEQKMSESSQ KFQEIEEAHL RQMKQLIKGY SHSVEDTHVQ VGQVHEEFKQ
NVENIGIENL IQKFAELKGT GKDKPALVGF EDYITALAPE GGKKSRAKAF RIPGLGKRDK
EPDSTFAVPA LQISSKNSPL EVDDEGFVIR SDSTQNDIEK ENNFYSSDSD FDDEEPKKFN
IQIRPVVNSN RSNAAATEKE LKATVGTLTL PPNRGSASLQ MESRRVCAGL PPAPTTAERT
LFNSFCIEML SSTVLGSDSL FGPPLESAFK SKSFDGGEQL RERRGFGASE YAAFSSDSSS
PENVEDSGLD SPSHPTLGPS PEPAGWAAWP PVSQSKEQTL SLPPPESESP GLCAPPRCQS
PAPPSLPPPP PAPASGAART DRPVPPGPVR HHRCRTSTRT TKDSVRQRRP DGSFKQEILS
SLFLASVHLS RGPSPISLST QEAWPVAAAI TEYISAYFKG GQHNRCLVKI TGDLTMSFPA
GITRIFTANP NVAVLSFRLV NISRIDHFLP NQKLLFSDPS QSDPDTRDFW FNMQALHLHL
QREAELNPQA SYYNVGIIKY QLSSQDPGRA PLLLSAECQR SGTVTRVSLD YHCCPATAPS
TQLTAVQVLL PLDHTATDLQ CQPPASWNAD ERRLLWKLPN LSPTNHSKGS GTLCASWQCL
SLAVQFVGSG TSLSGMDVEL VGSRYRMSLV KKRFATGKYM AGC
//
